New prostate cancer grade grouping system predicts survival after radical prostatectomy

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Erickson , A , Sandeman , K , Lahdensuo , K , Nordling , S , Kallajoki , M , Seikkula , H , Bützow , A , Vasarainen , H , Boström , P J , Taimen , P , Rannikko , A & Mirtti , T 2018 , ' New prostate cancer grade grouping system predicts survival after radical prostatectomy ' , Human Pathology , vol. 75 , pp. 159-166 . https://doi.org/10.1016/j.humpath.2018.01.027

Title: New prostate cancer grade grouping system predicts survival after radical prostatectomy
Author: Erickson, Andrew; Sandeman, Kevin; Lahdensuo, Kanerva; Nordling, Stig; Kallajoki, Markku; Seikkula, Heikki; Bützow, Anna; Vasarainen, Hanna; Boström, Peter J.; Taimen, Pekka; Rannikko, Antti; Mirtti, Tuomas
Contributor organization: Medicum
Institute for Molecular Medicine Finland
Department of Pathology
University of Helsinki
HUSLAB
Doctoral Programme in Clinical Research
Faculty of Medicine
Clinicum
Urologian yksikkö
Department of Surgery
HUS Abdominal Center
Date: 2018-05
Language: eng
Number of pages: 8
Belongs to series: Human Pathology
ISSN: 0046-8177
DOI: https://doi.org/10.1016/j.humpath.2018.01.027
URI: http://hdl.handle.net/10138/236621
Abstract: Histological Gleason grading of prostate cancer has been through modifications and conjoined into a Grade Grouping system recently. The aim of this study was to determine whether the new Grade Grouping system predicts disease-specific and all-cause mortality after radical prostatectomy. We constructed a clinical database consisting of all consecutively radical prostatectomy treated men between 1983 and 1998 and between 2000 and 2005 at the Helsinki University Hospital and at the Turku University Hospital, respectively. Patients' all-cause and prostate cancer specific mortality information was updated in November 2015 from the Finnish Cancer Registry. Secondary therapy information was also available from the patients' records at Helsinki. Univariate and multivariate statistical analyses were performed to assess predictive significance of the Grade Grouping system. Grade Grouping associated independently with increased risk of prostate cancer specific mortality within 15 years of follow-up in a multivariable model containing age at operation, diagnostic prostate-specific antigen, pathological stage and lymph node status at operation. Additionally, the all-cause mortality-free survival time and time to secondary therapies were different between the Grade Groups, emphasized in the subanalysis of Grade Groups 1-2 versus Grade Groups 3-5. We can conclude that the new Grade Grouping system is feasible in predicting prostate cancer specific survival after radical surgical treatment. Grade Grouping offers a simpler way to interpret the predicted course of the disease to individual patients and thus may help in justifying more conservative follow-up approaches, especially in the lower Grade Group patients. (C) 2018 The Authors. Published by Elsevier Inc.
Subject: Grade Group
Gleason grade
prostate cancer
survival
3122 Cancers
3126 Surgery, anesthesiology, intensive care, radiology
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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