Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women

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Mokkala , K , Pellonpera , O , Roytio , H , Pussinen , P , Ronnemaa , T & Laitinen , K 2017 , ' Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women ' , Metabolism, clinical and experimental , vol. 69 , pp. 43-50 . https://doi.org/10.1016/j.metabol.2016.12.015

Title: Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women
Author: Mokkala, Kati; Pellonpera, Outi; Roytio, Henna; Pussinen, Pirkko; Ronnemaa, Tapani; Laitinen, Kirsi
Other contributor: University of Helsinki, Clinicum



Date: 2017-04
Language: eng
Number of pages: 8
Belongs to series: Metabolism, clinical and experimental
ISSN: 0026-0495
DOI: https://doi.org/10.1016/j.metabol.2016.12.015
URI: http://hdl.handle.net/10138/236705
Abstract: Background. Increased intestinal permeability with subsequent metabolic endotoxemia, i.e., elevated circulating levels of bacterial lipopolysaccharide, LPS, has been introduced as a novel initiator of obesity related metabolic disturbances in non-pregnant individuals. The objective was to investigate the extent to which intestinal permeability, measured by serum zonulin concentration, is related to metabolic endotoxemia and metabolic risk markers in overweight pregnant women. Methods. This was a cross-sectional study including 100 pregnant overweight women in early pregnancy. Serum zonulin was analyzed using ELISA, and markers for metabolic endotoxemia (LPS), inflammation (high-sensitive C-reactive protein and glycoprotein acetylation GIyA), glucose metabolism (fasting glucose and insulin), and lipid metabolism were measured. Results. Higher serum zonulin concentration associated positively with LPS (P = 0.02), inflammatory markers (P <0.001), insulin (P <0.001), insulin resistance (P <0.001), and triglycerides (P = 0.001), and negatively with insulin sensitivity (P = 0.001) (ANOVA with Tukey's corrections or Kruskal-Wallis nonparametric test with Bonferroni correction for zonulin quartiles). All the observed associations were confirmed (P <0.015) in a linear regression model adjusted with potential confounding factors. Both LPS and GlycA showed positive relationship with insulin resistance, serum insulin, triglycerides, total and LDL-cholesterol and negative relationship with insulin sensitivity (P Conclusions. Our findings suggest that increased serum zonulin concentration, i.e., increased intestinal permeability, contributes to metabolic endotoxemia, systemic inflammation, and insulin resistance in overweight pregnant women. By reinforcingintestinal barrier, it may be possible to manipulate maternal metabolism during pregnancy with subsequent health benefits. (C) 2017 Elsevier Inc. All rights reserved.
Subject: Intestinal permeability
Low grade inflammation
Metabolic endotoxemia
Pregnancy
Overweight
C-REACTIVE PROTEIN
GESTATIONAL DIABETES-MELLITUS
HIGH-FAT DIET
GUT MICROBIOTA
INFLAMMATORY MARKERS
CIRCULATING ZONULIN
INSULIN SENSITIVITY
GLYCOPROTEIN LEVELS
MATERNAL OBESITY
ENDOTOXEMIA
3121 General medicine, internal medicine and other clinical medicine
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