Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring : A Nationwide Case-Control Study

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http://hdl.handle.net/10138/236753

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Leivonen , S , Scharf , J M , Mathews , C A , Chudal , R , Gyllenberg , D , Sucksdorff , D , Suominen , A , Voutilainen , A , Brown , A S & Sourander , A 2017 , ' Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring : A Nationwide Case-Control Study ' , Journal of the American Academy of Child and Adolescent Psychiatry , vol. 56 , no. 4 , pp. 297-303 . https://doi.org/10.1016/j.jaac.2017.01.009

Title: Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring : A Nationwide Case-Control Study
Author: Leivonen, Susanna; Scharf, Jeremiah M.; Mathews, Carol A.; Chudal, Roshan; Gyllenberg, David; Sucksdorff, Dan; Suominen, Auli; Voutilainen, Arja; Brown, Alan S.; Sourander, Andre
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
Date: 2017-04
Language: eng
Number of pages: 7
Belongs to series: Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 0890-8567
URI: http://hdl.handle.net/10138/236753
Abstract: Objective: To determine the associations between maternal and paternal psychiatric diagnoses and Tourette syndrome (TS)/chronic tic disorder (CT) in a nationwide study. Method: This nested case-control study linked data derived from three national registers. All singletons born and diagnosed with TS/CT in Finland between January 1991 and December 2010 were identified (n = 1,120) and matched to four controls (n = 4,299). Conditional logistic regression was used to examine the associations between parental psychopathology and TS/CT. Results: Altogether, 24.9% of patients with TS/CT and 12.00/0 of controls had a mother with a psychiatric diagnosis. Similarly, 17.9% and 12.9% had a father with a psychiatric diagnosis. Any maternal and any paternal psychiatric diagnosis was associated with offspring TS/CT (odds ratio [OR] 2.3; 95% CI 1.9-2.7 and OR 1.2; 95% CI 1.01-1.5, respectively). The association between maternal psychiatric diagnosis and TS/CT was stronger than that between paternal psychiatric diagnosis and TS/CT (p Conclusion: Parental psychiatric diagnoses (especially in the mother) are associated with diagnosed offspring TS/CT. Further studies are required before the results can be generalized to all children with TS/CT. The associations between maternal psychiatric disorders and TS may reflect both maternal specific environmental and/or genetic influences.
Subject: Tourette syndrome
parental psychiatric diagnoses
risk factor
OBSESSIVE-COMPULSIVE DISORDER
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
DEFICIT HYPERACTIVITY DISORDER
AUTISM SPECTRUM DISORDERS
PSYCHIATRIC-DISORDERS
SOCIOECONOMIC-STATUS
GENETIC-RELATIONSHIP
PERINATAL FACTORS
MATERNAL SMOKING
MENTAL-ILLNESS
3123 Gynaecology and paediatrics
3124 Neurology and psychiatry
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