Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

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Jelenkovic , A , Yokoyama , Y , Sund , R , Hur , Y-M , Harris , J R , Brandt , I , Nilsen , T S , Ooki , S , Ullemar , V , Almqvist , C , Magnusson , P K E , Saudino , K J , Stazi , M A , Fagnani , C , Brescianini , S , Nelson , T L , Whitfield , K E , Knafo-Noam , A , Mankuta , D , Abramson , L , Cutler , T L , Hopper , J L , Llewellyn , C H , Fisher , A , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Krueger , R F , McGue , M , Pahlen , S , Alexandra Burt , S , Klump , K L , Dubois , L , Boivin , M , Brendgen , M , Dionne , G , Vitaro , F , Willemsen , G , Bartels , M , van Beijsterveld , C E M , Craig , J M , Heikkilä , K , Pietiläinen , K H , Ning , F , Kaprio , J & Silventoinen , K 2018 , ' Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project ' , Early Human Development , vol. 120 , pp. 53-60 . https://doi.org/10.1016/j.earlhumdev.2018.04.004

Title: Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project
Author: Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Hur, Yoon-Mi; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas Sevenius; Ooki, Syuichi; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K.E.; Saudino, Kimberly J.; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Nelson, Tracy L.; Whitfield, Keith E.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Cutler, Tessa L.; Hopper, John L.; Llewellyn, Clare H.; Fisher, Abigail; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Alexandra Burt, S.; Klump, Kelly L.; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Willemsen, Gonneke; Bartels, Meike; van Beijsterveld, Catharina E.M.; Craig, Jeffrey M.; Heikkilä, Kauko; Pietiläinen, Kirsi H.; Ning, Feng; Kaprio, Jaakko; Silventoinen, Karri
Contributor: University of Helsinki, Academic Disciplines of the Faculty of Social Sciences
University of Helsinki, Research Units of the Faculty of Social Sciences
University of Helsinki, Department of Public Health
University of Helsinki, Research Programs Unit
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Academic Disciplines of the Faculty of Social Sciences
Date: 2018-05
Language: eng
Number of pages: 8
Belongs to series: Early Human Development
ISSN: 0378-3782
URI: http://hdl.handle.net/10138/236780
Abstract: Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
Subject: 3142 Public health care science, environmental and occupational health
BIRTH WEIGHT
BIRTH LENGTH
PONDERAL INDEX
HEIGHT
TWINS
POPULATION
FINAL HEIGHT
LENGTH
BODY-COMPOSITION
SHORT STATURE
FETAL ORIGINS HYPOTHESIS
CHILDHOOD GROWTH
CORONARY-HEART-DISEASE
WEIGHT
FOR-GESTATIONAL-AGE
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