Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study

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dc.contributor.author Rovio, Suvi P.
dc.contributor.author Pahkala, Katja
dc.contributor.author Nevalainen, Jaakko
dc.contributor.author Juonala, Markus
dc.contributor.author Salo, Pia
dc.contributor.author Kahonen, Mika
dc.contributor.author Hutri-Kahonen, Nina
dc.contributor.author Lehtimaki, Terho
dc.contributor.author Jokinen, Eero
dc.contributor.author Laitinen, Tomi
dc.contributor.author Taittonen, Leena
dc.contributor.author Tossavainen, Paivi
dc.contributor.author Viikari, Jorma S. A.
dc.contributor.author Rinne, Juha O.
dc.contributor.author Raitakari, Olli T.
dc.date.accessioned 2018-06-30T21:21:04Z
dc.date.available 2021-12-17T22:02:22Z
dc.date.issued 2017-05-09
dc.identifier.citation Rovio , S P , Pahkala , K , Nevalainen , J , Juonala , M , Salo , P , Kahonen , M , Hutri-Kahonen , N , Lehtimaki , T , Jokinen , E , Laitinen , T , Taittonen , L , Tossavainen , P , Viikari , J S A , Rinne , J O & Raitakari , O T 2017 , ' Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study ' , Journal of the American College of Cardiology , vol. 69 , no. 18 , pp. 2279-2289 . https://doi.org/10.1016/j.jacc.2017.02.060
dc.identifier.other PURE: 86206041
dc.identifier.other PURE UUID: be6c214b-f328-4b05-aa8f-5c846438f350
dc.identifier.other WOS: 000400247500005
dc.identifier.other Scopus: 85018415519
dc.identifier.uri http://hdl.handle.net/10138/236794
dc.description.abstract BACKGROUND In adults, high blood pressure (BP), adverse serum lipids, and smoking associate with cognitive deficits. The effects of these risk factors from childhood on midlife cognitive performance are unknown. OBJECTIVES This study sought to investigate the associations between childhood/adolescence cardiovascular risk factors and midlife cognitive performance. METHODS From 1980, a population-based cohort of 3,596 children (baseline age: 3 to 18 years) have been followed for 31 years in 3- to 9-year intervals. BP, serum lipids, body mass index, and smoking were assessed in all follow-ups. Cumulative exposure as the area under the curve for each risk factor was determined in childhood (6 to 12 years), adolescence (12 to 18 years), and young adulthood (18 to 24 years). In 2011, cognitive testing was performed in 2,026 participants aged 34 to 49 years. RESULTS High systolic BP, elevated serum total-cholesterol, and smoking from childhood were independently associated with worse midlife cognitive performance, especially memory and learning. The number of early life risk factors, including high levels (extreme 75th percentile for cumulative risk exposure between ages 6 and 24 years) of systolic BP, total-cholesterol, and smoking associated inversely with midlife visual and episodic memory and visuospatial associative learning (-0.140 standard deviations per risk factor, p <0.0001) and remained significant after adjustment for contemporaneous risk factors. Individuals with all risk factors within recommended levels between ages 6 and 24 years performed 0.29 standard deviations better (p = 0.006) on this cognitive domain than those exceeding all risk factor guidelines at least twice. This difference corresponds to the effect of 6 years aging on this cognitive domain. CONCLUSIONS Cumulative burden of cardiovascular risk factors from childhood/adolescence associate with worse midlife cognitive performance independent of adulthood exposure. (C) 2017 by the American College of Cardiology Foundation. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Journal of the American College of Cardiology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject blood pressure
dc.subject body mass index
dc.subject cognitive performance
dc.subject serum cholesterol
dc.subject smoking
dc.subject ALZHEIMERS-DISEASE
dc.subject OXIDATIVE STRESS
dc.subject CIGARETTE-SMOKE
dc.subject BLOOD-PRESSURE
dc.subject BRAIN
dc.subject DEMENTIA
dc.subject CHOLESTEROL
dc.subject ADULTS
dc.subject AGE
dc.subject INFLAMMATION
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jacc.2017.02.060
dc.relation.issn 0735-1097
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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