Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study

Show simple item record Rovio, Suvi P. Pahkala, Katja Nevalainen, Jaakko Juonala, Markus Salo, Pia Kahonen, Mika Hutri-Kahonen, Nina Lehtimaki, Terho Jokinen, Eero Laitinen, Tomi Taittonen, Leena Tossavainen, Paivi Viikari, Jorma S. A. Rinne, Juha O. Raitakari, Olli T. 2018-06-30T21:21:04Z 2021-12-17T22:02:22Z 2017-05-09
dc.identifier.citation Rovio , S P , Pahkala , K , Nevalainen , J , Juonala , M , Salo , P , Kahonen , M , Hutri-Kahonen , N , Lehtimaki , T , Jokinen , E , Laitinen , T , Taittonen , L , Tossavainen , P , Viikari , J S A , Rinne , J O & Raitakari , O T 2017 , ' Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study ' , Journal of the American College of Cardiology , vol. 69 , no. 18 , pp. 2279-2289 .
dc.identifier.other PURE: 86206041
dc.identifier.other PURE UUID: be6c214b-f328-4b05-aa8f-5c846438f350
dc.identifier.other WOS: 000400247500005
dc.identifier.other Scopus: 85018415519
dc.description.abstract BACKGROUND In adults, high blood pressure (BP), adverse serum lipids, and smoking associate with cognitive deficits. The effects of these risk factors from childhood on midlife cognitive performance are unknown. OBJECTIVES This study sought to investigate the associations between childhood/adolescence cardiovascular risk factors and midlife cognitive performance. METHODS From 1980, a population-based cohort of 3,596 children (baseline age: 3 to 18 years) have been followed for 31 years in 3- to 9-year intervals. BP, serum lipids, body mass index, and smoking were assessed in all follow-ups. Cumulative exposure as the area under the curve for each risk factor was determined in childhood (6 to 12 years), adolescence (12 to 18 years), and young adulthood (18 to 24 years). In 2011, cognitive testing was performed in 2,026 participants aged 34 to 49 years. RESULTS High systolic BP, elevated serum total-cholesterol, and smoking from childhood were independently associated with worse midlife cognitive performance, especially memory and learning. The number of early life risk factors, including high levels (extreme 75th percentile for cumulative risk exposure between ages 6 and 24 years) of systolic BP, total-cholesterol, and smoking associated inversely with midlife visual and episodic memory and visuospatial associative learning (-0.140 standard deviations per risk factor, p <0.0001) and remained significant after adjustment for contemporaneous risk factors. Individuals with all risk factors within recommended levels between ages 6 and 24 years performed 0.29 standard deviations better (p = 0.006) on this cognitive domain than those exceeding all risk factor guidelines at least twice. This difference corresponds to the effect of 6 years aging on this cognitive domain. CONCLUSIONS Cumulative burden of cardiovascular risk factors from childhood/adolescence associate with worse midlife cognitive performance independent of adulthood exposure. (C) 2017 by the American College of Cardiology Foundation. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Journal of the American College of Cardiology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject blood pressure
dc.subject body mass index
dc.subject cognitive performance
dc.subject serum cholesterol
dc.subject smoking
dc.subject BRAIN
dc.subject DEMENTIA
dc.subject CHOLESTEROL
dc.subject ADULTS
dc.subject AGE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0735-1097
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S073510971736120X_main.pdf 660.7Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record