Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease

Show simple item record Kakela, Pirjo Mannisto, Ville Ilves, Imre Vaittinen, Maija Tauriainen, Milla-Maria Eskelinen, Matti Gylling, Helena Paajanen, Hannu Pihlajamaki, Jussi 2018-07-01T21:21:05Z 2021-12-17T22:02:33Z 2017-05
dc.identifier.citation Kakela , P , Mannisto , V , Ilves , I , Vaittinen , M , Tauriainen , M-M , Eskelinen , M , Gylling , H , Paajanen , H & Pihlajamaki , J 2017 , ' Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease ' , Obesity Surgery , vol. 27 , no. 5 , pp. 1284-1291 .
dc.identifier.other PURE: 86254728
dc.identifier.other PURE UUID: ba921dd2-1d58-479e-9950-88585add5d5e
dc.identifier.other WOS: 000400029400023
dc.identifier.other Scopus: 84994311343
dc.description.abstract Gallstone disease (GD) has been associated with low serum levels of plant sterols. We evaluated the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and non-alcoholic fatty liver disease (NAFLD) on the association of GD with low levels of serum plant sterols. Two hundred forty-two consecutive morbidly obese patients were recruited to this prospective study. Histological analysis of liver biopsy to diagnose NAFLD was performed. Bile sample was taken during the LRYGB. Associations of GD with serum non-cholesterol sterol to cholesterol ratios, measured using gas liquid chromatography and with mRNA expression of genes participating in the cholesterol, bile, and fatty acid metabolism in the liver, were analyzed. Out of the 242 participants, 95 had GD. Lower weight (p = 0.002) and female sex (p = 0.0006) were associated with GD. Serum plant sterols, campesterol (p = 0.003), sitosterol (p = 0.002), and avenasterol (p = 0.015), were lower in patients with GD compared to those without GD. This association remained significant after adjustment for NAFLD, use of statin medication, and previous laparoscopic cholecystectomy (LCC). Levels of sitosterol (p = 0.001) and campesterol (p = 0.001) remained lower in obese individuals with GD also after obesity surgery. Liver mRNA expression of genes regulating cholesterol synthesis and bile metabolism was increased in individuals with GD. Serum plant sterols were lower in patients with GD independent of NAFLD, history of LCC, use of statin medication, and weight loss after LRYGB. Low serum plant sterols in patients with GD suggest potentially inherited alterations in sterol absorption and biliary transport in subjects susceptible for GD. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Obesity Surgery
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Laparoscopic roux-en-Y gastric bypass
dc.subject Obesity
dc.subject Statins
dc.subject Gallstones
dc.subject Weight loss
dc.subject Plant sterols
dc.subject ABSORPTION
dc.subject ABCG8
dc.subject RISK
dc.subject EXPRESSION
dc.subject SPECTRUM
dc.subject THERAPY
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease en
dc.type Article
dc.contributor.organization Department of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization HUS Abdominal Center
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0960-8923
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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