Canine breeds associated with gastric carcinoma, metaplasia and dysplasia diagnosed by histopathology of endoscopic biopsy samples

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dc.contributor.author Candido, Marcus Vinicius
dc.contributor.author Syrjä, Pernilla
dc.contributor.author Kilpinen, Susanne
dc.contributor.author Spillmann, Thomas
dc.date.accessioned 2018-07-05T10:14:01Z
dc.date.available 2018-07-05T10:14:01Z
dc.date.issued 2018-06-18
dc.identifier.citation Candido , M V , Syrjä , P , Kilpinen , S & Spillmann , T 2018 , ' Canine breeds associated with gastric carcinoma, metaplasia and dysplasia diagnosed by histopathology of endoscopic biopsy samples ' , Acta Veterinaria Scandinavica , vol. 60 , 37 . https://doi.org/10.1186/s13028-018-0392-6
dc.identifier.other PURE: 108674260
dc.identifier.other PURE UUID: f560e7e1-c266-47cc-a565-18669ed15116
dc.identifier.other WOS: 000435944600002
dc.identifier.other Scopus: 85048955957
dc.identifier.other ORCID: /0000-0001-9740-2636/work/51806391
dc.identifier.uri http://hdl.handle.net/10138/236959
dc.description Correction: Candido et al. Acta Vet Scand, (2020) 62:25
dc.description.abstract Background: Gastric carcinoma (GC) is a rather rare pathological finding in dogs, with the exception of some breeds which seem predisposed. The etiopathogenesis is largely unknown in dogs, whereas in humans GC often develops from gastric mucosal metaplasia and dysplasia. This study investigates whether dogs of certain breeds are more often subject to gastroduodenoscopy (GDS), and diagnosed with GC, mucosal metaplasia or dysplasia. A retrospective clinical database search was performed at the Veterinary Teaching Hospital at the University of Helsinki, Finland. The following inclusion criteria were applied to estimate relative risk for metaplasia/dysplasia and GC: dogs from pure breeds with at least five individuals subject to GDS with histopathology of gastric biopsies. Results: Between 2006 and 2016, from a total of 54945 canine patients presented, 423 dogs underwent GDS. Inclusion criteria were met in 180 dogs of 20 different pure breeds. Eight dogs had GCs (mean age = 9.8 +/- 1.7 years): Belgian Tervuren (n = 4), Collie (n = 2), Golden Retriever (n = 1) and Jack Russel Terrier (n = 1). Fourteen dogs of eight breeds had gastric mucosal metaplasia or dysplasia. A log-binomial statistical model revealed that dogs in the following breeds had a significantly higher probability to undergo GDS than the others in the study population: Australian Terrier, Belgian Tervuren, Cairn Terrier, Collie and Siberian Husky. Belgian Tervuren was found at higher risk to be diagnosed with GC [RR = 19 (5.7-63.9; P <0.0001)], as well as mucosal metaplasia/dysplasia [RR (7.6; 2.95-19.58; P <0.0001)], as compared to the other breeds included. Shetland Sheepdog had an increased RR (5.83; 1.75-19.45; P = 0.0041) for metaplasia. Conclusions: The results indicate a very low incidence of GC in dogs. The Belgian Tervuren, however, appears as predisposed. The histopathologic descriptions of mucosal changes such as metaplasia and dysplasia were also rare, but were more frequent in the Belgian Tervuren. Previous reports of these changes in dogs are very scarce, but they might be presumably related to GC in dogs, as they are in humans. Future research should investigate the possible role of metaplasia and dysplasia in the development of GC in dogs, especially those of predisposed breeds. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Acta Veterinaria Scandinavica
dc.rights cc_by
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Breed predisposition
dc.subject Cancer
dc.subject Dog
dc.subject Dysplasia
dc.subject Endoscopy
dc.subject Gastric carcinoma
dc.subject Gastroduodenoscopy
dc.subject Metaplasia
dc.subject DOGS
dc.subject CANCER
dc.subject CATS
dc.subject NEOPLASIA
dc.subject CHROMOENDOSCOPY
dc.subject LUNDEHUND
dc.subject INFECTION
dc.subject DISEASE
dc.subject POLYPS
dc.subject 413 Veterinary science
dc.title Canine breeds associated with gastric carcinoma, metaplasia and dysplasia diagnosed by histopathology of endoscopic biopsy samples en
dc.type Article
dc.contributor.organization Departments of Faculty of Veterinary Medicine
dc.contributor.organization Equine and Small Animal Medicine
dc.contributor.organization Faculty of Veterinary Medicine
dc.contributor.organization Veterinary Pathology and Parasitology
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Antti Sukura / Principal Investigator
dc.contributor.organization Thomas Spillmann / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s13028-018-0392-6
dc.relation.issn 0044-605X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.type.version publishedVersion

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