Toe Pressure and Toe Brachial Index are Predictive of Cardiovascular Mortality, Overall Mortality, and Amputation Free Survival in Patients with Peripheral Artery Disease

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dc.contributor.author Wickstrom, J. -E.
dc.contributor.author Laivuori, Mirjami
dc.contributor.author Aro, E.
dc.contributor.author Sund, R. T.
dc.contributor.author Hautero, O.
dc.contributor.author Venermo, Maarit
dc.contributor.author Jalkanen, J.
dc.contributor.author Hakovirta, H.
dc.date.accessioned 2018-07-05T21:20:03Z
dc.date.available 2021-12-17T22:02:51Z
dc.date.issued 2017-05
dc.identifier.citation Wickstrom , J -E , Laivuori , M , Aro , E , Sund , R T , Hautero , O , Venermo , M , Jalkanen , J & Hakovirta , H 2017 , ' Toe Pressure and Toe Brachial Index are Predictive of Cardiovascular Mortality, Overall Mortality, and Amputation Free Survival in Patients with Peripheral Artery Disease ' , European Journal of Vascular and Endovascular Surgery , vol. 53 , no. 5 , pp. 696-703 . https://doi.org/10.1016/j.ejvs.2017.02.012
dc.identifier.other PURE: 86542551
dc.identifier.other PURE UUID: 90e874f2-26c5-4384-9989-18a76faf3504
dc.identifier.other WOS: 000401678900019
dc.identifier.other Scopus: 85014817501
dc.identifier.other ORCID: /0000-0002-6268-8117/work/39205841
dc.identifier.uri http://hdl.handle.net/10138/236975
dc.description.abstract Objective/Background: Peripheral haemodynamic parameters are used to assess the presence and severity of peripheral artery disease (PAD). The prognostic value of ankle brachial index (ABI) has been thoroughly delineated. Nonetheless, the relative usefulness of ankle pressure (AP), ABI, toe pressure (TP), and toe brachial index (TBI) in assessing patient outcome has not been investigated in a concurrent study setting. This study aimed to resolve the association of all four non-invasive haemodynamic parameters in clinically symptomatic patients with PAD with cardiovascular mortality, overall mortality, and amputation free survival (AFS). Methods: In total, 732 symptomatic patients with PAD admitted to the Department of Vascular Surgery for conventional angiography at Turku University Hospital, Turku, Finland, between January 2009 and August 2011 were reviewed retrospectively. Demographic factors, cardiovascular mortality, all-cause mortality, and above foot level amputations were obtained and assessed in relation to AP, ABI, TP, and TBI by means of Kaplan-Meier life tables and a multivariate Cox regression model. Results: The haemodynamic parameter that was associated with poor 36 month general outcome was TP <30 mmHg. Univariate Cox regression analysis of stratified values showed that TP and TBI associated significantly with mortality. In multivariate analysis both TP and TBI were associated with a significant risk of death. For TP <30 mmHg and TBI <0.25 the risk of cardiovascular mortality was hazard ratio [HR] 2.84, 95% confidence interval [CI] 1.75-4.61 [p Conclusion: Among non-invasive haemodynamic measurements and pressure indices both TP and TBI appear to be associated with cardiovascular and overall mortality and AFS for patients with PAD presenting symptoms of the disease. (C) 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof European Journal of Vascular and Endovascular Surgery
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ABI
dc.subject Amputation free survival
dc.subject Ankle pressure
dc.subject Mortality
dc.subject TBI
dc.subject Toe pressure
dc.subject CRITICAL LIMB ISCHEMIA
dc.subject DIGITAL BLOOD-PRESSURE
dc.subject TERM FOLLOW-UP
dc.subject INCREASED RISK
dc.subject TASC-II
dc.subject REVASCULARIZATION
dc.subject EVENTS
dc.subject RECONSTRUCTION
dc.subject ADULTS
dc.subject MODEL
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Toe Pressure and Toe Brachial Index are Predictive of Cardiovascular Mortality, Overall Mortality, and Amputation Free Survival in Patients with Peripheral Artery Disease en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Verisuonikirurgian yksikkö
dc.contributor.organization Department of Surgery
dc.contributor.organization Department of Social Research (2010-2017)
dc.contributor.organization Centre for Social Data Science, CSDS
dc.contributor.organization HUS Abdominal Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejvs.2017.02.012
dc.relation.issn 1078-5884
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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