Submandibular gland cancer : Specific features and treatment considerations

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http://hdl.handle.net/10138/237038

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Aro , K , Tarkkanen , J , Saat , R , Saarilahti , K , Mäkitie , A & Atula , T 2018 , ' Submandibular gland cancer : Specific features and treatment considerations ' , Head & Neck , vol. 40 , no. 1 , pp. 154-162 . https://doi.org/10.1002/hed.24981

Title: Submandibular gland cancer : Specific features and treatment considerations
Author: Aro, Katri; Tarkkanen, Jussi; Saat, Riste; Saarilahti, Kauko; Mäkitie, Antti; Atula, Timo
Contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Oncology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-01
Language: eng
Number of pages: 9
Belongs to series: Head & Neck
ISSN: 1043-3074
URI: http://hdl.handle.net/10138/237038
Abstract: BackgroundIn the absence of unified treatment protocol, we evaluated the management and outcomes of submandibular gland cancers in an unselected patient series. MethodsWe included all patients with resected submandibular gland cancer treated at the Helsinki University Hospital from 2000 to 2010 with a 5-year minimum follow-up. ResultsTwenty-five patients with cancer represented 30% of submandibular gland neoplasms, and most were adenoid cystic carcinomas (ACCs; 56%). At presentation, 3 patients showed clinical signs of probable malignancy. Of 22 neck dissection specimens, 5 patients (20%) had metastases with an occult metastasis rate of 4%. Cancer recurred in 11 patients (44%), of which 7 (28%) were only at a distant site. The 5-year disease-specific survival (DSS) and overall survival (OS) rates were 76%, and disease-free survival (DFS) was 68%. ConclusionMost tumors were ACCs differing from the histological pattern of parotid gland cancers. Occult metastases were rare. The rarity of submandibular gland cancer, its variable histological pattern, and varying biological behavior warrant centralized management.
Subject: cancer
imaging
outcome
salivary gland
treatment
ADENOID CYSTIC CARCINOMA
SALIVARY DUCT CARCINOMA
CONCURRENT CHEMORADIOTHERAPY
ADJUVANT CHEMORADIOTHERAPY
DISTANT METASTASES
DATA-BASE
TUMORS
NECK
RADIOTHERAPY
MANAGEMENT
3125 Otorhinolaryngology, ophthalmology
3122 Cancers
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