Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

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Matikainen , N , Söderlund , S , Björnson , E , Bogl , L H , Pietiläinen , K H , Hakkarainen , A , Lundbom , N , Eliasson , B , Räsänen , S , Rivellese , A , Patti , L , Prinster , A , Riccardi , G , Despres , J -P , Almeras , N , Holst , J J , Deacon , C F , Boren , J & Taskinen , M -R 2017 , ' Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men ' , Nutrition, Metabolism and Cardiovascular Diseases , vol. 27 , no. 6 , pp. 534-542 . https://doi.org/10.1016/j.numecd.2017.03.003

Title: Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
Author: Matikainen, N.; Söderlund, S.; Björnson, E.; Bogl, L. H.; Pietiläinen, K. H.; Hakkarainen, A.; Lundbom, N.; Eliasson, B.; Räsänen, Sari; Rivellese, A.; Patti, L.; Prinster, A.; Riccardi, G.; Despres, J. -P.; Almeras, N.; Holst, J. J.; Deacon, C. F.; Boren, J.; Taskinen, M. -R.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Abdominal Center
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Clinicum
Date: 2017-06
Language: eng
Number of pages: 9
Belongs to series: Nutrition, Metabolism and Cardiovascular Diseases
ISSN: 0939-4753
URI: http://hdl.handle.net/10138/237043
Abstract: Background and aims: Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in the pathogenesis of metabolic syndrome and type 2 diabetes. Epidemiologic studies consistently link high fructose consumption to insulin resistance but whether fructose consumption impairs the incretin response remains unknown. Methods and results: As many as 66 obese (BMI 26-40 kg/m(2)) male subjects consumed fructose-sweetened beverages containing 75 g fructose/day for 12 weeks while continuing their usual lifestyle. Glucose, insulin, GLP-1 and GIP were measured during oral glucose tolerance test (OGTT) and triglycerides (TG), GLP-1, GIP and PYY during a mixed meal test before and after fructose intervention. Fructose intervention did not worsen glucose and insulin responses during OGTT, and GLP-1 and GIP responses during OGTT and fat-rich meal were unchanged. Postprandial TG response increased significantly, p = 0.004, and we observed small but significant increases in weight and liver fat content, but not in visceral or subcutaneous fat depots. However, even the subgroups who gained weight or liver fat during fructose intervention did not worsen their glucose, insulin, GLP-1 or PYY responses. A minor increase in GIP response during OGTT occurred in subjects who gained liver fat (p = 0.049). Conclusion: In obese males with features of metabolic syndrome, 12 weeks fructose intervention 75 g/day did not change glucose, insulin, GLP-1 or GIP responses during OGTT or GLP-1, GIP or PYY responses during a mixed meal. Therefore, fructose intake, even accompanied with mild weight gain, increases in liver fat and worsening of postprandial TG profile, does not impair glucose tolerance or gut incretin response to oral glucose or mixed meal challenge. (C) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Subject: Glucagon-like peptide 1
Glucose-dependent insulinotropic polypeptide
Fructose intervention
Incretin response
Liver fat
Metabolic syndrome
Mixed meal test
Oral glucose tolerance test
INSULIN SENSITIVITY
SWEETENED BEVERAGES
VISCERAL FAT
CORN SYRUP
INTRAHEPATIC LIPIDS
DIABETES-MELLITUS
LIVER FAT
CONSUMPTION
HUMANS
SUCROSE
3121 General medicine, internal medicine and other clinical medicine
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