Automated classification of neonatal sleep states using EEG

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Koolen , N , Oberdorfer , L , Rona , Z , Giordano , V , Werther , T , Klebermass-Schrehof , K , Stevenson , N & Vanhatalo , S 2017 , ' Automated classification of neonatal sleep states using EEG ' , Clinical Neurophysiology , vol. 128 , no. 6 , pp. 1100-1108 . https://doi.org/10.1016/j.clinph.2017.02.025

Title: Automated classification of neonatal sleep states using EEG
Author: Koolen, Ninah; Oberdorfer, Lisa; Rona, Zsofia; Giordano, Vito; Werther, Tobias; Klebermass-Schrehof, Katrin; Stevenson, Nathan; Vanhatalo, Sampsa
Contributor organization: HUS Medical Imaging Center
Department of Neurosciences
Clinicum
Kliinisen neurofysiologian yksikkö
Children's Hospital
Lastentautien yksikkö
HUS Children and Adolescents
Date: 2017-06
Language: eng
Number of pages: 9
Belongs to series: Clinical Neurophysiology
ISSN: 1388-2457
DOI: https://doi.org/10.1016/j.clinph.2017.02.025
URI: http://hdl.handle.net/10138/237061
Abstract: Objective: To develop a method for automated neonatal sleep state classification based on EEG that can be applied over a wide range of age. Methods: We collected 231 EEG recordings from 67 infants between 24 and 45 weeks of postmenstrual age. Ten minute epochs of 8 channel polysomnography (N = 323) from active and quiet sleep were used as a training dataset. We extracted a set of 57 EEG features from the time, frequency, and spatial domains. A greedy algorithm was used to define a reduced feature set to be used in a support vector machine classifier. Results: Performance tests showed that our algorithm was able to classify quiet and active sleep epochs with 85% accuracy, 83% sensitivity, and 87% specificity. The performance was not substantially lowered by reducing the epoch length or EEG channel number. The classifier output was used to construct a novel trend, the sleep state probability index, that improves the visualisation of brain state fluctuations. Conclusions: A robust EEG-based sleep state classifier was developed. It performs consistently well across a large span of postmenstrual ages. Significance: This method enables the visualisation of sleep state in preterm infants which can assist clinical management in the neonatal intensive care unit. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Subject: Neonatal EEG
Brain monitoring
Sleep-wake cycling
Classification
Support vector machine
AMPLITUDE-INTEGRATED EEG
DETRENDED FLUCTUATION ANALYSIS
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
WEEKS GESTATIONAL-AGE
PRETERM INFANTS
PREMATURE-INFANTS
MATURATIONAL CHANGES
BRAIN MATURATION
TIME-SERIES
WAKE CYCLES
3124 Neurology and psychiatry
3112 Neurosciences
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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