Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report

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Krieg , S M , Lioumis , P , Mäkelä , J P , Wilenius , J , Karhu , J , Hannula , H , Savolainen , P , Weiss , C L , Seidel , K , Laakso , A , Islam , M , Vaalto , S , Lehtinen , H , Vitikainen , A-M , Tarapore , P E & Picht , T 2017 , ' Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report ' , Acta Neurochirurgica , vol. 159 , no. 7 , pp. 1187-1195 . https://doi.org/10.1007/s00701-017-3187-z

Title: Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report
Author: Krieg, Sandro M.; Lioumis, Pantelis; Mäkelä, Jyrki P.; Wilenius, Juha; Karhu, Jari; Hannula, Henri; Savolainen, Petri; Weiss, Carolin Lucas; Seidel, Kathleen; Laakso, Aki; Islam, Mominul; Vaalto, Selja; Lehtinen, Henri; Vitikainen, Anne-Mari; Tarapore, Phiroz E.; Picht, Thomas
Contributor: University of Helsinki, BioMag Laboratory
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Clinicum
University of Helsinki, University Hospital of Cologne
University of Helsinki, University of Bern
University of Helsinki, Department of Neurosciences
University of Helsinki, Department of Neurosciences
University of Helsinki, Lastenneurologian yksikkö
University of Helsinki, Sauli Savolainen / Principal Investigator
University of Helsinki, University of California
University of Helsinki, Charite Medical University of Berlin
Date: 2017-07
Language: eng
Number of pages: 9
Belongs to series: Acta Neurochirurgica
ISSN: 0001-6268
URI: http://hdl.handle.net/10138/237090
Abstract: Navigated transcranial magnetic stimulation (nTMS) is increasingly used for preoperative mapping of motor function, and clinical evidence for its benefit for brain tumor patients is accumulating. In respect to language mapping with repetitive nTMS, literature reports have yielded variable results, and it is currently not routinely performed for presurgical language localization. The aim of this project is to define a common protocol for nTMS motor and language mapping to standardize its neurosurgical application and increase its clinical value. The nTMS workshop group, consisting of highly experienced nTMS users with experience of more than 1500 preoperative nTMS examinations, met in Helsinki in January 2016 for thorough discussions of current evidence and personal experiences with the goal to recommend a standardized protocol for neurosurgical applications. nTMS motor mapping is a reliable and clinically validated tool to identify functional areas belonging to both normal and lesioned primary motor cortex. In contrast, this is less clear for language-eloquent cortical areas identified by nTMS. The user group agreed on a core protocol, which enables comparison of results between centers and has an excellent safety profile. Recommendations for nTMS motor and language mapping protocols and their optimal clinical integration are presented here. At present, the expert panel recommends nTMS motor mapping in routine neurosurgical practice, as it has a sufficient level of evidence supporting its reliability. The panel recommends that nTMS language mapping be used in the framework of clinical studies to continue refinement of its protocol and increase reliability.
Subject: Brain tumor
Epilepsy surgery
Motor
Language
Preoperative mapping
Transcranial magnetic stimulation
TRANSCRANIAL MAGNETIC STIMULATION
BRAIN-STIMULATION
NEUROSURGICAL PATIENTS
CORTICAL STIMULATION
CORTICOSPINAL TRACT
NAMING ERRORS
HAND AREA
RESECTION
SPEECH
NTMS
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
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