Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men?

Show simple item record Wesolowska, Karolina Elovainio, Marko Koponen, Mikael Tuiskula, Annukka M. Hintsanen, Mirka Keltikangas-Jarvinen, Liisa Maattanen, Ilmari Swan, Heikki Hintsa, Taina 2018-07-11T21:35:10Z 2018-07-11T21:35:10Z 2017-06
dc.identifier.citation Wesolowska , K , Elovainio , M , Koponen , M , Tuiskula , A M , Hintsanen , M , Keltikangas-Jarvinen , L , Maattanen , I , Swan , H & Hintsa , T 2017 , ' Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men? ' , Journal of Genetic Counseling , vol. 26 , no. 3 , pp. 491-500 .
dc.identifier.other PURE: 86809339
dc.identifier.other PURE UUID: 0893c6a0-0b95-4feb-8570-28f793bfb44a
dc.identifier.other WOS: 000400568900011
dc.identifier.other Scopus: 84983423014
dc.identifier.other ORCID: /0000-0002-7977-3852/work/39203325
dc.identifier.other ORCID: /0000-0003-3765-8343/work/39203945
dc.identifier.other ORCID: /0000-0001-9738-8547/work/39206047
dc.description.abstract We examined whether long QT syndrome (LQTS) mutation carrier status or symptomatic LQTS are associated with depression, and whether there are sex differences in these potential relationships. The sample comprised 782 participants (252 men). Of the 369 genetically defined LQTS mutation carriers, 169 were symptomatic and 200 were asymptomatic. The control group consisted of 413 unaffected relatives. Depression was assessed using the Beck Depression Inventory-II (BDI-II). No association was found for LQTS mutation carrier status with depression. The multinomial logistic regression showed that LQTS mutation carrier men with arrhythmic events scored higher on depression compared with the control group, even when adjusting for age, beta-blockers, antidepressants, and social support (OR = 1.09, 95 % CI [1.02, 1.15], p = .007). The binary logistic regression comparing symptomatic and asymptomatic LQTS mutation carriers showed that symptomatic LQTS was associated with depression in men (OR = 1.10, 95 % CI [1.03, 1.19], p = .009). The results were unchanged when additionally adjusted for education. These findings suggest that symptomatic LQTS is associated with depression in men but not in women. Overall, however, depression is more frequent in women than men. Thus, regular screening for depression in LQTS mutation carriers and their unaffected family members can be important. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Journal of Genetic Counseling
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Arrhythmia
dc.subject Depression
dc.subject Long QTsyndrome (LQTS)
dc.subject Sex differences
dc.subject RISK
dc.subject GENDER
dc.subject POPULATION
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 1184 Genetics, developmental biology, physiology
dc.subject 515 Psychology
dc.title Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men? en
dc.type Article
dc.contributor.organization Medicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Psychosocial factors and health
dc.contributor.organization Doctoral Programme in Clinical Research
dc.contributor.organization Clinicum
dc.contributor.organization Kimmo Kontula Research Group
dc.contributor.organization Department of Medicine
dc.contributor.organization HUS Heart and Lung Center
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1059-7700
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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