Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest

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Herajarvi , J , Anttila , T , Dimova , E Y , Laukka , T , Myllymaki , M , Haapanen , H , Olenchock , B A , Tuominen , H , Puistola , U , Karihtala , P , Kiviluoma , K , Koivunen , P , Anttila , V & Juvonen , T 2017 , ' Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest ' , Scandinavian Cardiovascular Journal , vol. 51 , no. 4 , pp. 233-241 . https://doi.org/10.1080/14017431.2017.1319574

Title: Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest
Author: Herajarvi, Johanna; Anttila, Tuomas; Dimova, Elitsa Y.; Laukka, Tuomas; Myllymaki, Mikko; Haapanen, Henri; Olenchock, Benjamin A.; Tuominen, Hannu; Puistola, Ulla; Karihtala, Peeter; Kiviluoma, Kai; Koivunen, Peppi; Anttila, Vesa; Juvonen, Tatu
Other contributor: University of Helsinki, Clinicum



Date: 2017
Language: eng
Number of pages: 9
Belongs to series: Scandinavian Cardiovascular Journal
ISSN: 1401-7431
DOI: https://doi.org/10.1080/14017431.2017.1319574
URI: http://hdl.handle.net/10138/237095
Abstract: Objectives. During aortic and cardiac surgery, risks for mortality and morbidity are inevitable. Surgical setups involving deep hypothermic circulatory arrest (DHCA) are effective to achieve organ protection against ischemic injury. The aim of this study was to identify humoural factors mediating additive protective effects of remote ischemic preconditioning (RIPC) in a porcine model of DHCA. Design. Twenty-two pigs were randomized into the RIPC group (n=11) and the control group (n=11). The RIPC group underwent four 5-minute hind limb ischemia-reperfusion cycles prior to cardiopulmonary bypass and DHCA. All animals underwent identical surgical procedures including 60min DHCA at 18 degrees C. Blood samples were collected from vena cava and sagittal sinus at several time points. After the 8-hour follow-up period, the brain, heart, and kidney tissue samples were collected for tissue analyses. Results. Serum levels of brain damage marker S100B recovered faster in the RIPC group, after 4hours of the arrest, (p
Subject: Remote ischemic preconditioning
hypothermic circulatory arrest
humoural factors
MYOCARDIAL PROTECTION
REPERFUSION INJURY
CARDIAC-SURGERY
SURVIVAL
OUTCOMES
HEART
MECHANISMS
EFFLUENT
BYPASS
REPAIR
3121 General medicine, internal medicine and other clinical medicine
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