Fibroblasts in the Tumor Microenvironment : Shield or Spear?

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http://hdl.handle.net/10138/237102

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Alkasalias , T , Moyano-Galceran , L , Arsenian-Henriksson , M & Lehti , K 2018 , ' Fibroblasts in the Tumor Microenvironment : Shield or Spear? ' International Journal of Molecular Sciences , vol. 19 , no. 5 , 1532 . DOI: 10.3390/ijms19051532

Title: Fibroblasts in the Tumor Microenvironment : Shield or Spear?
Author: Alkasalias, Twana; Moyano-Galceran, Lidia; Arsenian-Henriksson, Marie; Lehti, Kaisa
Contributor: University of Helsinki, Genome-Scale Biology (GSB) Research Program
Date: 2018-05
Number of pages: 21
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/237102
Abstract: Tumorigenesis is a complex process involving dynamic interactions between malignant cells and their surrounding stroma, including both the cellular and acellular components. Within the stroma, fibroblasts represent not only a predominant cell type, but also a major source of the acellular tissue microenvironment comprising the extracellular matrix (ECM) and soluble factors. Normal fibroblasts can exert diverse suppressive functions against cancer initiating and metastatic cells via direct cell-cell contact, paracrine signaling by soluble factors, and ECM integrity. The loss of such suppressive functions is an inherent step in tumor progression. A tumor cell-induced switch of normal fibroblasts into cancer-associated fibroblasts (CAFs), in turn, triggers a range of pro-tumorigenic signals accompanied by distraction of the normal tissue architecture, thus creating an optimal niche for cancer cells to grow extensively. To further support tumor progression and metastasis, CAFs secrete factors such as ECM remodeling enzymes that further modify the tumor microenvironment in combination with the altered adhesive forces and cell-cell interactions. These paradoxical tumor suppressive and promoting actions of fibroblasts are the focus of this review, highlighting the heterogenic molecular properties of both normal and cancer-associated fibroblasts, as well as their main mechanisms of action, including the emerging impact on immunomodulation and different therapy responses.
Subject: normal fibroblasts
cancer-associated fibroblasts
neighbor suppression
cancer
desmoplasia
therapy
CANCER-ASSOCIATED FIBROBLASTS
EPITHELIAL-MESENCHYMAL TRANSITION
CARCINOMA-ASSOCIATED FIBROBLASTS
HUMAN-LUNG FIBROBLASTS
GROWTH IN-VIVO
BREAST-CANCER
EXTRACELLULAR-MATRIX
STROMAL FIBROBLASTS
TGF-BETA
CELL INVASION
3111 Biomedicine
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