The Epigenetic Clock at Birth : Associations With Maternal Antenatal Depression and Child Psychiatric Problems

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Suarez , A , Lahti , J , Czamara , D , Lahti-Pulkkinen , M , Knight , A K , Girchenko , P , Hämäläinen , E , Kajantie , E , Lipsanen , J , Laivuori , H , Villa , P M , Reynolds , R M , Smith , A K , Binder , E B & Räikkönen , K 2018 , ' The Epigenetic Clock at Birth : Associations With Maternal Antenatal Depression and Child Psychiatric Problems ' , Journal of the American Academy of Child and Adolescent Psychiatry , vol. 57 , no. 5 , pp. 321-+ . https://doi.org/10.1016/j.jaac.2018.02.011

Title: The Epigenetic Clock at Birth : Associations With Maternal Antenatal Depression and Child Psychiatric Problems
Author: Suarez, Anna; Lahti, Jari; Czamara, Darina; Lahti-Pulkkinen, Marius; Knight, Anna K.; Girchenko, Polina; Hämäläinen, Esa; Kajantie, Eero; Lipsanen, Jari; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Smith, Alicia K.; Binder, Elisabeth B.; Räikkönen, Katri
Contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Medicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Medicum
Date: 2018-05
Language: eng
Number of pages: 10
Belongs to series: Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 0890-8567
URI: http://hdl.handle.net/10138/237105
Abstract: Objective: Maternal antenatal depression may compromise the fetal developmental milieu and contribute to individual differences in aging and disease trajectories in later life. We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems. Method: A total of 694 mothers from the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) Study provided information on history of depression diagnosed before pregnancy; 581 completed the Center for Epidemiological Studies Depression Scale throughout pregnancy, and 407 completed the Child Behavior Checklist at child's age 3.7 years (SD = 0.75 year). DNA methylation (DNAm) GA of fetal cord blood DNA was based on the methylation profile of 148 selected cytosine linked to guanine by phosphate (CpG) sites. Epigenetic GA was calculated as the arithmetic difference between DNAm GA and chronological GA and adjusted for chronological GA. Results: Maternal history of depression diagnosed before pregnancy (mean difference = -0.25 SD units, 95% CI = -0.46 to -0.03) and greater antenatal depressive symptoms (-0.08 SD unit per I-SD unit increase, 95% CI = -0.16 to -0.004) were associated with child's lower epigenetic GA. Child's lower epigenetic GA, in turn, prospectively predicted total and internalizing problems and partially mediated the effects of maternal antenatal depression on internalizing problems in boys. Conclusion: Maternal antenatal depression is associated with lower epigenetic GA in offspring. This lower epigenetic GA seems to be associated with a developmental disadvantage for boys, who, in early childhood, show greater psychiatric problems.
Subject: epigenetic clock
gestational age
cord blood
antenatal depression
childhood psychiatric problem
DNA METHYLATION
SYMPTOMS
PREGNANCY
COHORT
SEX-DIFFERENCES
STRESS
CELL-TYPES
EXPOSURE
AGE
515 Psychology
3124 Neurology and psychiatry
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