Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan

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http://hdl.handle.net/10138/237144

Lähdeviite

Harris , V , Ali , A , Fuentes , S , Korpela , K , Kazi , M , Tate , J , Parashar , U , Wiersinga , W J , Giaquinto , C , de Weerth , C & de Vos , W M 2018 , ' Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan ' , Gut Microbes , vol. 9 , no. 2 , pp. 93-101 . https://doi.org/10.1080/19490976.2017.1376162

Julkaisun nimi: Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan
Tekijä: Harris, Vanessa; Ali, Asad; Fuentes, Susana; Korpela, Katri; Kazi, Momin; Tate, Jacqueline; Parashar, Umesh; Wiersinga, W. Joost; Giaquinto, Carlo; de Weerth, Carolina; de Vos, Willem M.
Tekijän organisaatio: Department of Bacteriology and Immunology
Medicum
Päiväys: 2018
Kieli: eng
Sivumäärä: 9
Kuuluu julkaisusarjaan: Gut Microbes
ISSN: 1949-0976
DOI-tunniste: https://doi.org/10.1080/19490976.2017.1376162
URI: http://hdl.handle.net/10138/237144
Tiivistelmä: Rotavirus (RV) is the leading cause of diarrhea-related death in children worldwide and ninety-five percent of rotavirus deaths occur in Africa and Asia. Rotavirus vaccines (RVV) can dramatically reduce RV deaths, but have low efficacy in low-income settings where they are most needed. The intestinal microbiome may contribute to this decreased RVV efficacy. This pilot study hypothesizes that infants' intestinal microbiota composition correlates with RVV immune responses and that RVV responders have different gut microbiota as compared to non-responders. We conducted a nested, matched case-control study comparing the pre-vaccination intestinal microbiota composition between 10 6-week old Pakistani RVV-responders, 10 6-week old Pakistani RVV non-responders, and 10 healthy Dutch infants. RVV response was defined as an Immunoglobulin A of >= 20 IU/mL following Rotarix (TM)(RV1) vaccination in an infant with aprevaccination IgA RV1 response correlated with a higher relative abundance of bacteria belonging to Clostridium cluster XI and Proteobacteria, including bacteria related to Serratia and Escherichia coli. Remarkably, abundance of these Proteobacteria was also significantly higher in Dutch infants when compared to RV1-non-responders in Pakistan. This small but carefully matched study showed the intestinal microbiota composition to correlate with RV1 seroconversion in Pakistan infants, identifying signatures shared with healthy Dutch infants.
Avainsanat: intestinal microbes
seroconversion
rotavirus vaccine
vaccine immunogenicity
1ST 2 YEARS
PHYLOGENETIC MICROARRAY
DOUBLE-BLIND
INTESTINAL MICROBIOTA
AFRICAN INFANTS
SECRETOR STATUS
EFFICACY
GASTROENTERITIS
IMMUNOGENICITY
MONOVALENT
3121 General medicine, internal medicine and other clinical medicine
1183 Plant biology, microbiology, virology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: unspecified
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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