Micro-computed tomography, scanning electron microscopy and energy X-ray spectroscopy studies of facet joint degeneration : A comparison to clinical imaging

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Göhre , F , Ludtka , C , Hamperl , M , Friedmann , A , Straube , A , Mendel , T , Heilmann , A , Meisel , H J & Schwan , S 2017 , ' Micro-computed tomography, scanning electron microscopy and energy X-ray spectroscopy studies of facet joint degeneration : A comparison to clinical imaging ' , Micron , vol. 100 , pp. 50-59 . https://doi.org/10.1016/j.micron.2017.04.011

Title: Micro-computed tomography, scanning electron microscopy and energy X-ray spectroscopy studies of facet joint degeneration : A comparison to clinical imaging
Author: Göhre, Felix; Ludtka, Christopher; Hamperl, Melanie; Friedmann, Andrea; Straube, Anja; Mendel, Thomas; Heilmann, Andreas; Meisel, Hans Jorg; Schwan, Stefan
Contributor organization: Department of Neurosciences
Clinicum
HUS Neurocenter
Date: 2017-09
Language: eng
Number of pages: 10
Belongs to series: Micron
ISSN: 0968-4328
DOI: https://doi.org/10.1016/j.micron.2017.04.011
URI: http://hdl.handle.net/10138/237201
Abstract: Segmental degeneration in the human lumbar spine affects both the intervertebral discs and facet joints. Facet joint degeneration not only affects the cartilage surface, but also alters the cellular properties of the cartilage tissue and the structure of the subchondral bone. The primary focus of this study is the investigation of these microstructural changes that are caused by facet joint degeneration. Microstructural analyses of degenerated facet joint samples, obtained from patients following operative lumbar interbody fusion, have not previously been extensively investigated. This study analyzes human facet joint samples from the inferior articular process using scanning electron microscopy, micro-computed tomography, and energy dispersive X-ray spectroscopy to evaluate parameters of interest in facet joint degeneration such as elemental composition, cartilage layer thickness and cell density, calcification zone thickness, subchondral bone portion, and trabecular bone porosity. These microstructural analyses demonstrate fragmentation, cracking, and destruction of the cartilage layer, a thickened calcification zone, localized calcification areas, and cell cluster formation as pathological manifestations of facet joint degeneration. The detailed description of these microstructural changes is critical for a comprehensive understanding of the pathology of facet joint degeneration, as well as the subsequent development and efficacy analysis of regenerative treatment strategies.
Subject: Computed tomography
Facet joint
Human lumbar spine
Scanning electron microscopy
Structure analysis
LUMBAR INTERBODY FUSION
INTERVERTEBRAL DISC DEGENERATION
SUBCHONDRAL MINERALIZED ZONE
ARTICULAR-CARTILAGE
IN-VITRO
OSTEOARTHRITIS
SPINE
CALCIFICATION
DISEASE
BONE
3112 Neurosciences
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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