Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases

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Cserni , G , Floris , G , Koufopoulos , N , Kovacs , A , Nonni , A , Regitnig , P , Ståhls , A & Varga , Z 2017 , ' Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases ' , Virchows Archiv , vol. 471 , no. 1 , pp. 3-12 . https://doi.org/10.1007/s00428-017-2147-6

Title: Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases
Author: Cserni, Gabor; Floris, Giuseppe; Koufopoulos, Nektarios; Kovacs, Aniko; Nonni, Afroditi; Regitnig, Peter; Ståhls, Anders; Varga, Zsuzsanna
Contributor: University of Helsinki, HUSLAB
Date: 2017-07
Language: eng
Number of pages: 10
Belongs to series: Virchows Archiv
ISSN: 0945-6317
URI: http://hdl.handle.net/10138/237255
Abstract: Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation. All but one of the eight cases occurred in postmenopausal patients. Extracellular mucin production was present in 5 to 50% of the tumour samples and rarely also appeared in nodal and distant metastases. The tumours were completely E-cadherin negative and showed cytoplasmic p120 positivity. The majority (n = 6/8) was also completely negative for beta-catenin, but two tumours displayed focal beta-catenin positivity in the mucinous area. MUC1 and MUC2 expression was observed in all and 7/8 tumours, respectively; neuroendocrine differentiation was present in only one. Invasive lobular carcinoma with extracellular mucin formation is a rare morphologic variant of lobular carcinoma prone to be misdiagnosed and warranting further studies.
Subject: Breast cancer
E-cadherin
Extracellular mucin
Lobular carcinoma
Mucinous carcinoma
E-CADHERIN
CLINICAL ONCOLOGY/COLLEGE
AMERICAN SOCIETY
VARIANT
EXPRESSION
CANCER
DIFFERENTIATION
RECOMMENDATIONS
ADENOCARCINOMA
LESIONS
3111 Biomedicine
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