CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens

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Qiu , T , Yang , Y , Qiu , J , Huang , Y , Xu , T , Xiao , H , Wu , D , Zhang , Q , Zhou , C , Zhang , X , Tang , K , Xu , J & Cao , Z 2018 , ' CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens ' , Nature Communications , vol. 9 , 1772 . https://doi.org/10.1038/s41467-018-04171-2

Title: CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens
Author: Qiu, Tianyi; Yang, Yiyan; Qiu, Jingxuan; Huang, Yang; Xu, Tianlei; Xiao, Han; Wu, Dingfeng; Zhang, Qingchen; Zhou, Chen; Zhang, Xiaoyan; Tang, Kailin; Xu, Jianqing; Cao, Zhiwei
Other contributor: University of Helsinki, Department of Computer Science
Date: 2018-05-02
Language: eng
Number of pages: 10
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-04171-2
URI: http://hdl.handle.net/10138/237521
Abstract: Major challenges in vaccine development include rapidly selecting or designing immunogens for raising cross-protective immunity against different intra-or inter-subtypic pathogens, especially for the newly emerging varieties. Here we propose a computational method, Conformational Epitope (CE)-BLAST, for calculating the antigenic similarity among different pathogens with stable and high performance, which is independent of the prior binding-assay information, unlike the currently available models that heavily rely on the historical experimental data. Tool validation incorporates influenza-related experimental data sufficient for stability and reliability determination. Application to dengue-related data demonstrates high harmonization between the computed clusters and the experimental serological data, undetectable by classical grouping. CE-BLAST identifies the potential cross-reactive epitope between the recent zika pathogen and the dengue virus, precisely corroborated by experimental data. The high performance of the pathogens without the experimental binding data suggests the potential utility of CE-BLAST to rapidly design cross-protective vaccines or promptly determine the efficacy of the currently marketed vaccine against emerging pathogens, which are the critical factors for containing emerging disease outbreaks.
Subject: INFLUENZA-VIRUS
STRUCTURAL BASIS
ZIKA VIRUS
PROTEIN
NEUTRALIZATION
ANTIBODIES
HEMAGGLUTININ
DETERMINANTS
SPECIFICITY
RECOGNITION
3111 Biomedicine
113 Computer and information sciences
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