Cancer risk of Lichen planus : A cohort study of 13,100 women in Finland

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Halonen , P , Jakobsson , M , Heikinheimo , O , Riska , A , Gissler , M & Pukkala , E 2018 , ' Cancer risk of Lichen planus : A cohort study of 13,100 women in Finland ' , International Journal of Cancer , vol. 142 , no. 1 , pp. 18-22 . https://doi.org/10.1002/ijc.31025

Title: Cancer risk of Lichen planus : A cohort study of 13,100 women in Finland
Author: Halonen, Pia; Jakobsson, Maija; Heikinheimo, Oskari; Riska, Annika; Gissler, Mika; Pukkala, Eero
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2018-01-01
Language: eng
Number of pages: 5
Belongs to series: International Journal of Cancer
ISSN: 0020-7136
URI: http://hdl.handle.net/10138/237763
Abstract: The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n=13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with subsequent cancer diagnoses from the Finnish Cancer Registry until 2014. Standardized incidence ratios (SIRs) were counted for different cancers by dividing the observed numbers of cancers by expected numbers, which were based on national cancer incidence rates. In total, 1,520 women with LP were diagnosed with cancer (SIR 1.15, 95% confidence interval [CI] 1.09-1.20). LP was associated with an increased risk of cancer of lip (SIR 5.17, 95% CI 3.06-8.16), cancer of tongue (SIR 12.4, 95% CI 9.45-16.0), cancer of oral cavity (SIR 7.97, 95% CI 6.79-9.24), cancer of esophagus (SIR 1.95, 95% CI 1.17-3.04), cancer of larynx (SIR of 3.47, 95% CI 1.13-8.10) and cancer of vulva (SIR 1.99, 95% CI 1.18-3.13). The risk of cancer was not increased in other locations where LP manifests (pharynx and skin). Patients with diagnosed LP have an increased risk of developing cancer of lip, tongue, oral cavity, esophagus, larynx and vulva. These data are important when considering treatment and follow-up of patients with LP diagnosis. What's new?Lichen planus (LP) is a chronic disease of the skin and mucous membranes that is likely autoimmune in origin. Owing to its inflammatory nature, it is also suspected of causing certain cancers. Whether LP possesses malignant potential, however, remains uncertain. Here, in a cohort of 13,100 women diagnosed with LP between 1969 and 2012 in Finland, some 1,520 were eventually diagnosed with cancer. Malignancies with significant increases in incidence in LP patients included those of the lip, tongue, oral cavity, esophagus, larynx and vulva. The findings suggest that LP patients could benefit from multidisciplinary approaches to care.
Subject: 3122 Cancers
Lichen planus
cancer risk
oral cancer
vulvar cancer
SQUAMOUS-CELL CARCINOMA
OF-THE-LITERATURE
MALIGNANT-TRANSFORMATION
DIAGNOSTIC-CRITERIA
VULVA
INVOLVEMENT
ESOPHAGEAL
POPULATION
QUALITY
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