Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)

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Chaudhry , S R , Hafez , A , Rezai Jahromi , B , Kinfe , T M , Lamprecht , A , Niemelä , M & Muhammad , S 2018 , ' Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH) ' , International Journal of Molecular Sciences , vol. 19 , no. 7 , 2035 . https://doi.org/10.3390/ijms19072035

Title: Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)
Author: Chaudhry, Shafqat Rasul; Hafez, Ahmad; Rezai Jahromi, Behnam; Kinfe, Thomas Mehari; Lamprecht, Alf; Niemelä, Mika; Muhammad, Sajjad
Contributor organization: Neurokirurgian yksikkö
Clinicum
University of Helsinki
HUS Neurocenter
Date: 2018-07-13
Language: eng
Number of pages: 20
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms19072035
URI: http://hdl.handle.net/10138/237843
Abstract: Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes, but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical clipping and endovascular coiling can successfully obliterate the bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute and chronic hydrocephalus, seizures, cortical spreading depression, delayed ischemic neurological deficits, and delayed cerebral ischemia lead to poor clinical outcomes. The mechanisms leading to these complications are complex and poorly understood. Early brain injury resulting from transient global ischemia can release molecules that may be critical to initiate and sustain inflammatory response. Hence, the events during early brain injury can influence the occurrence of delayed brain injury. Since the damage associated molecular pattern molecules (DAMPs) might be the initiators of inflammation in the pathophysiology of aSAH, so the aim of this review is to highlight their role in the context of aSAH from diagnostic, prognostic, therapeutic, and drug therapy monitoring perspectives. DAMPs represent a diverse and a heterogenous group of molecules derived from different compartments of cells upon injury. Here, we have reviewed the most important DAMPs molecules including high mobility group box-1 (HMGB1), S100B, hemoglobin and its derivatives, extracellular matrix components, IL-1α, IL-33, and mitochondrial DNA in the context of aSAH and their role in post-aSAH complications and clinical outcome after aSAH.
Subject: 3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
subarachnoid hemorrhage
danger associated molecular pattern molecules (DAMPs)
alarmins
high mobility group box-1 (HMGB1)
S100B
mitochondrial DNA
hemoglobin
interleukin (IL)-33
IL-1 alpha
heat shock proteins
TOLL-LIKE RECEPTORS
GROUP BOX 1
DELAYED CEREBRAL-ISCHEMIA
BASILAR ARTERY VASOSPASM
MITOCHONDRIAL-DNA LEVELS
INNATE IMMUNE-RESPONSES
CENTRAL-NERVOUS-SYSTEM
EARLY BRAIN-INJURY
CEREBROSPINAL-FLUID
S-100 PROTEIN
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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