Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols : Dehydration Versus Dimerization

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Kolsi , L E , Yli-Kauhaluoma , J & Moreira , V M 2018 , ' Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols : Dehydration Versus Dimerization ' , ACS Omega , vol. 3 , no. 8 , pp. 8836–8842 . https://doi.org/10.1021/acsomega.8b01401

Title: Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols : Dehydration Versus Dimerization
Author: Kolsi, Laura E.; Yli-Kauhaluoma, Jari; Moreira, Vânia M.
Other contributor: University of Helsinki, Pharmaceutical Design and Discovery group
University of Helsinki, Pharmaceutical Design and Discovery group
University of Helsinki, Pharmaceutical Design and Discovery group




Date: 2018-08-09
Language: eng
Number of pages: 7
Belongs to series: ACS Omega
ISSN: 2470-1343
DOI: https://doi.org/10.1021/acsomega.8b01401
URI: http://hdl.handle.net/10138/238077
Abstract: Bi(OTf)(3)center dot xH(2)O is a powerful catalyst for the dehydration of tertiary alcohols into alkenes in apolar solvents. The reaction proceeds smoothly and selectively, with amounts as low as 0.01 mol % catalyst, in yields up to 93%. Moreover, in polar solvents, Bi(OTf)(3)center dot xOH(2)O (0.1-1 mol %) selectively catalyzes the dimerization of the alcohols instead, forming new C-C bonds, in yields up to 96%. This mild, efficient, economic, and eco-friendly method is applicable across different chemical classes and amenable to several functional groups.
Subject: 317 Pharmacy
ORGANIC-SYNTHESIS
ACID
HETERODIMERIZATION
CONSTRUCTION
DITERPENOIDS
CHEMISTRY
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