Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola

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dc.contributor University of Helsinki, HUS Children and Adolescents en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka en
dc.contributor University of Helsinki, HUS Medical Imaging Center en
dc.contributor University of Helsinki, HUS Medical Imaging Center en
dc.contributor.author Karppinen, Mariia
dc.contributor.author Sjövall, Atte
dc.contributor.author Pelkonen, Tuula
dc.contributor.author Bernardino, Luis
dc.contributor.author Roine, Irmeli
dc.contributor.author Pitkäranta, Anne
dc.contributor.author Aarnisalo, Antti A
dc.contributor.author Nevalainen, Päivi
dc.contributor.author Lauronen, Leena
dc.date.accessioned 2018-08-14T07:51:01Z
dc.date.available 2018-08-14T07:51:01Z
dc.date.issued 2018-01-01
dc.identifier.citation Karppinen , M , Sjövall , A , Pelkonen , T , Bernardino , L , Roine , I , Pitkäranta , A , Aarnisalo , A A , Nevalainen , P & Lauronen , L 2018 , ' Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola ' , Clinical medicine insights. Ear, nose and throat , vol. 11 , 1179550618758648 . https://doi.org/10.1177/1179550618758648 en
dc.identifier.issn 1179-5506
dc.identifier.other PURE: 99726942
dc.identifier.other PURE UUID: 413eb4fc-9172-4083-9630-1141c6bf44ab
dc.identifier.other RIS: urn:18AFD2C467C2CC00EB2E1C0F5E6FB63B
dc.identifier.other ORCID: /0000-0003-2784-8186/work/82467495
dc.identifier.other ORCID: /0000-0003-1300-2323/work/86938380
dc.identifier.uri http://hdl.handle.net/10138/238340
dc.description.abstract Objective:To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola.Methods:The morphology of ABR traces of 221 children (aged 2?months to 12?years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces were compared with mortality and mortality or severe neurological injury in subgroup analyses. Outcome was also evaluated with repeated ABR of 166 children based on presence or absence of responses at 80?dB nHL (normal hearing level) stimulation level.Results:Individually, the absence of typical ABR waveform did not signify poor outcome. At the group level, latencies and interpeak latencies (IPLs) were significantly prolonged among patients with BM in comparison with controls, and the prolongation correlated with higher mortality or severe neurological sequelae.Conclusions:We confirmed the effect of BM on neural conduction time in auditory pathway. However, ABR in similar settings seems not useful for individual prognostication, although at the group level, delayed latencies, IPLs, or both associated with poorer outcome. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Clinical medicine insights. Ear, nose and throat
dc.rights en
dc.subject 3123 Gynaecology and paediatrics en
dc.title Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola en
dc.type Article
dc.identifier.doi https://doi.org/10.1177/1179550618758648
dc.type.uri info:eu-repo/semantics/other
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