Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

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Geerlings , S Y , Kostopoulos , I , de Vos , W M & Belzer , C 2018 , ' Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How? ' , Microorganisms , vol. 6 , no. 3 , 75 . https://doi.org/10.3390/microorganisms6030075

Title: Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?
Author: Geerlings, Sharon Y.; Kostopoulos, Ioannis; de Vos, Willem M.; Belzer, Clara
Other contributor: University of Helsinki, Medicum






Date: 2018-09
Language: eng
Number of pages: 26
Belongs to series: Microorganisms
ISSN: 2076-2607
DOI: https://doi.org/10.3390/microorganisms6030075
URI: http://hdl.handle.net/10138/238343
Abstract: Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.
Subject: 3111 Biomedicine
1183 Plant biology, microbiology, virology
Akkermansia muciniphila
mucin
gut microbiota
ecological niches
digestive tract
human breast milk
IRRITABLE-BOWEL-SYNDROME
HUMAN GUT MICROBIOME
CHAIN FATTY-ACIDS
SMALL-INTESTINAL MICROBIOTA
MUCIN-DEGRADING BACTERIUM
HUMAN-MILK
MUCUS LAYERS
BILE-ACID
VERMIFORM APPENDIX
GALLBLADDER BILE
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