Early life stress and frailty in old age : the Helsinki birth cohort study

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dc.contributor.author Haapanen, M. J
dc.contributor.author Perälä, M. M
dc.contributor.author Salonen, M. K
dc.contributor.author Kajantie, E.
dc.contributor.author Simonen, M.
dc.contributor.author Pohjolainen, P.
dc.contributor.author Pesonen, A. K
dc.contributor.author Räikkönen, K.
dc.contributor.author Eriksson, J. G
dc.contributor.author von Bonsdorff, M. B
dc.date.accessioned 2018-08-19T03:24:31Z
dc.date.available 2018-08-19T03:24:31Z
dc.date.issued 2018-08-13
dc.identifier.citation BMC Geriatrics. 2018 Aug 13;18(1):179
dc.identifier.uri http://hdl.handle.net/10138/238735
dc.description.abstract Abstract Background Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried’s criteria. Results Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.
dc.language.iso eng
dc.publisher BioMed Central
dc.subject Early life stress
dc.subject Frailty
dc.subject Life-course
dc.subject Natural experiment
dc.subject Risk factor
dc.title Early life stress and frailty in old age : the Helsinki birth cohort study en
dc.date.updated 2018-08-19T03:24:31Z
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.rights.copyrightholder The Author(s).

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