Familial Ovarian Cancer Clusters with Other Cancers
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Zheng , G , Yu , H , Kanerva , A , Försti , A , Sundquist , K & Hemminki , K 2018 , ' Familial Ovarian Cancer Clusters with Other Cancers ' , Scientific Reports , vol. 8 , 11561 . https://doi.org/10.1038/s41598-018-29888-4
| Title: | Familial Ovarian Cancer Clusters with Other Cancers |
| Author: | Zheng, Guoqiao; Yu, Hongyao; Kanerva, Anna; Försti, Asta; Sundquist, Kristina; Hemminki, Kari |
| Contributor organization: | Clinicum Department of Oncology Department of Obstetrics and Gynecology University of Helsinki |
| Date: | 2018-08-01 |
| Language: | eng |
| Number of pages: | 10 |
| Belongs to series: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | https://doi.org/10.1038/s41598-018-29888-4 |
| URI: | http://hdl.handle.net/10138/238984 |
| Abstract: | Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend |
| Subject: |
NONPOLYPOSIS COLORECTAL-CANCER
GALLBLADDER CANCER LYNCH SYNDROME BREAST-CANCER RISK-FACTORS MUTATIONS POPULATION SUSCEPTIBILITY ASSOCIATIONS CARCINOMA 3111 Biomedicine 3122 Cancers |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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