Familial Ovarian Cancer Clusters with Other Cancers

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Zheng , G , Yu , H , Kanerva , A , Försti , A , Sundquist , K & Hemminki , K 2018 , ' Familial Ovarian Cancer Clusters with Other Cancers ' , Scientific Reports , vol. 8 , 11561 . https://doi.org/10.1038/s41598-018-29888-4

Title: Familial Ovarian Cancer Clusters with Other Cancers
Author: Zheng, Guoqiao; Yu, Hongyao; Kanerva, Anna; Försti, Asta; Sundquist, Kristina; Hemminki, Kari
Contributor: University of Helsinki, Clinicum
Date: 2018-08-01
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/238984
Abstract: Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend
Subject: NONPOLYPOSIS COLORECTAL-CANCER
GALLBLADDER CANCER
LYNCH SYNDROME
BREAST-CANCER
RISK-FACTORS
MUTATIONS
POPULATION
SUSCEPTIBILITY
ASSOCIATIONS
CARCINOMA
3111 Biomedicine
3122 Cancers
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