Health-related quality of life in relation to shark symptomatic and radiographic definitions of knee osteoarthritis : data from Osteoarthritis Initiative (OAI) 4-year follow- up study

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Törmälehto , S , Mononen , M E , Aarnio , E , Arokoski , J P A , Korhonen , R K & Martikainen , J 2018 , ' Health-related quality of life in relation to shark symptomatic and radiographic definitions of knee osteoarthritis : data from Osteoarthritis Initiative (OAI) 4-year follow- up study ' , Health and Quality of Life Outcomes , vol. 16 , 154 . https://doi.org/10.1186/s12955-018-0979-7

Title: Health-related quality of life in relation to shark symptomatic and radiographic definitions of knee osteoarthritis : data from Osteoarthritis Initiative (OAI) 4-year follow- up study
Author: Törmälehto, Soili; Mononen, Mika E.; Aarnio, Emma; Arokoski, Jari P. A.; Korhonen, Rami K.; Martikainen, Janne
Other contributor: University of Helsinki, Clinicum



Date: 2018-07-31
Language: eng
Number of pages: 12
Belongs to series: Health and Quality of Life Outcomes
ISSN: 1477-7525
DOI: https://doi.org/10.1186/s12955-018-0979-7
URI: http://hdl.handle.net/10138/239097
Abstract: Background: The purpose was to quantify the decrement in health utility (referred as disutility) associated with knee osteoarthritis (OA) and different symptomatic and radiographic uni- and bilateral definitions of knee OA in a repeated measures design of persons with knee OA or at increased risk of developing knee OA. Methods: Data were obtained from the Osteoarthritis Initiative database. SF-12 health-related quality of life was converted into SF-6D utilities, and were then handled as the health utility loss by subtracting 1.000 from the utility score, yielding a negative value (disutility). Symptomatic OA was defined by radiographic findings (Kellgren-Lawrence, K-L, grade >= 2) and frequent knee pain in the same knee. Radiographic OA was defined by five different definitions (K-L >= 2 unilaterally / bilaterally, or the highest / mean / combination of K-L grades of both knees). Repeated measures generalized estimating equation (GEE) models were used to investigate disutility in relation to these different definitions. Results: Utility decreased with worsening of symptomatic or radiographic status of knee OA. The participants with bilateral and unilateral symptomatic knee OA had 0.03 (p <0.001) and 0.02 (p <0.001) points lower utility scores, respectively, compared with the reference group. The radiographic K-L grade 4 defined as the mean or the highest grade of both knees was related to a decrease of 0.04 (p <0.001) and 0.03 (p <0.001) points in utility scores, respectively, compared to the reference group. Conclusions: Knee OA is associated with diminished health-related quality of life. Health utility can be quantified in relation to both symptomatic and radiographic uni- and bilateral definitions of knee OA, and these definitions are associated with differing disutilities. The performance of symptomatic definition was better, indicating that pain experience is an important factor in knee OA related quality of life.
Subject: Knee osteoarthritis
Health-related quality of life
SF-12
SF-6D
GENERALIZED ESTIMATING EQUATIONS
POPULATION-BASED SAMPLE
VALUE SET
PREVALENCE
INSTRUMENT
ARTHRITIS
OUTCOMES
EQ-5D
HIP
3141 Health care science
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