A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects

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Sloan , T J , Jalanka , J , Major , G A D , Krishnasamy , S , Pritchard , S , Abdelrazig , S , Korpela , K , Singh , G , Mulvenna , C , Hoad , C L , Marciani , L , Barrett , D A , Lomer , M C E , de Vos , W M , Gowland , P A & Spiller , R C 2018 , ' A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects ' , PLoS One , vol. 13 , no. 7 , 0201410 . https://doi.org/10.1371/journal.pone.0201410

Title: A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects
Author: Sloan, Tim J.; Jalanka, Jonna; Major, Giles A. D.; Krishnasamy, Shanthi; Pritchard, Sue; Abdelrazig, Salah; Korpela, Katri; Singh, Gulzar; Mulvenna, Claire; Hoad, Caroline L.; Marciani, Luca; Barrett, David A.; Lomer, Miranda C. E.; de Vos, Willem M.; Gowland, Penny A.; Spiller, Robin C.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Medicum
Date: 2018-07-26
Language: eng
Number of pages: 18
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/239256
Abstract: Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviation. Restricting FODMAP intake is believed to relieve colonic distension by reducing colonic fermentation but this has not been previously directly assessed. We performed a randomised controlled trial comparing the effect of a low FODMAP diet combined with either maltodextrin or oligofructose on colonic contents, metabolites and microbiota. Methods A parallel randomised controlled trial in healthy adults (n = 37). All subjects followed a low FODMAP diet for a week and supplemented their diet with either maltodextrin (MD) or oligofructose (OF) 7g twice daily. Fasted assessments performed pre- and post-diet included MRI to assess colonic volume, breath testing for hydrogen and methane, and stool collection for microbiota analysis. Results The low FODMAP diet was associated with a reduction in Bifidobacterium and breath hydrogen, which was reversed by oligofructose supplementation. The difference in breath hydrogen between groups post-intervention was 27ppm (95% CI 7 to 50, P Conclusion A low FODMAP diet reduces total bacterial count and gas production with little effect on colonic volume.
Subject: IRRITABLE-BOWEL-SYNDROME
RANDOMIZED CONTROLLED-TRIAL
REDUCES SYMPTOMS
GUT MICROBIOTA
BIFIDOBACTERIA
INULIN
TIME
MRI
PREBIOTICS
BACTERIAL
3111 Biomedicine
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