Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance : a prospective cohort study

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http://hdl.handle.net/10138/239790

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Hakkarainen , H , Huopio , H , Cederberg , H , Voutilainen , R & Heinonen , S 2018 , ' Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance : a prospective cohort study ' , BMC Pregnancy and Childbirth , vol. 18 , 326 . https://doi.org/10.1186/s12884-018-1958-z

Title: Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance : a prospective cohort study
Author: Hakkarainen, Heidi; Huopio, Hanna; Cederberg, Henna; Voutilainen, Raimo; Heinonen, Seppo
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2018-08-10
Language: eng
Number of pages: 7
Belongs to series: BMC Pregnancy and Childbirth
ISSN: 1471-2393
URI: http://hdl.handle.net/10138/239790
Abstract: Background: Whether the delivery of a large-for-gestational-age (LGA) infant predicts future maternal metabolic syndrome (MetS) is not known. To this aim, we investigated the incidence of MetS and its components in women with or without a history of gestational diabetes mellitus (GDM) with a view to the birth weight of the offspring. Methods: Eight hundred seventy six women treated for their pregnancies in Kuopio University Hospital in 19892009 underwent a follow-up study (mean follow-up time 7.3 (SD 5.1) years), of whom 489 women with GDM and 385 normoglycemic controls. The women were stratified into two groups according to the newborn's birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and > 90th percentile (LGA) (n = 116). MetS and its components were evaluated in the follow-up study according to the International Diabetes Federation criteria. Results: LGA vs. AGA delivery was associated with a higher incidence of MetS at follow-up in women with a background of GDM (54.4% vs. 43.6%), but not in women without GDM. Conclusion: An LGA delivery in women with GDM is associated with a higher risk of future MetS and this group is optimal to study preventive measures for MetS. In contrast, an LGA delivery after a normoglycemic pregnancy was not associated with an increased future maternal MetS risk.
Subject: Gestational diabetes mellitus
Metabolic syndrome
Large-for-gestational-age
Birth weight
DIABETES-MELLITUS
BIRTH-WEIGHT
CARDIOVASCULAR-DISEASE
FOLLOW-UP
PREGNANCY
AGE
ASSOCIATION
3123 Gynaecology and paediatrics
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