Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor

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Vesterinen , T , Mononen , S , Salmenkivi , K , Mustonen , H , Ilonen , I , Knuuttila , A , Haglund , C & Arola , J 2018 , ' Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor ' , Acta Oncologica , vol. 57 , no. 8 , pp. 1109-1116 . https://doi.org/10.1080/0284186X.2018.1441543

Title: Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor
Author: Vesterinen, Tiina; Mononen, Sanna; Salmenkivi, Kaisa; Mustonen, Harri; Ilonen, Ilkka; Knuuttila, Aija; Haglund, Caj; Arola, Johanna
Contributor: University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, Clinicum
University of Helsinki, Department of Surgery
University of Helsinki, Department of Medicine
University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, Medicum
Date: 2018
Language: eng
Number of pages: 8
Belongs to series: Acta Oncologica
ISSN: 0284-186X
URI: http://hdl.handle.net/10138/240216
Abstract: Background: Pulmonary carcinoids (PC) are rare malignant neoplasms that cover approximately 1% of all lung cancers. PCs are classified by histological criteria as either typical (TC) or atypical (AC). Histological subtype is the most studied prognostic factor. The aim of this study was to evaluate if other tissue or clinical features are associated with patient outcomes.Material and methods: We retrospectively reviewed clinical records of 133PC patients who underwent operation in the Helsinki University Hospital between 1990 and 2013. Tissue specimens were re-evaluated, processed into tissue microarray format and stained immunohistochemically with serotonin, calcitonin, adrenocorticotropic hormone (ACTH), thyroid transcription factor-1 (TTF-1) and Ki-67. Survival and risk analyses were performed.Results: Based on histology, 75% (n=100) of the tumors were TCs and 25% (n=33) ACs. TCs had higher 10-year disease-specific survival (DSS) rate than ACs (99% (95% CI, 93-100%) for TCs vs. 82% (95% CI, 61-92%) for ACs). Hormonally active tumors expressing serotonin, calcitonin or ACTH were noted in 53% of the specimens but hormonal expression was not associated with DSS. TTF-1 was positive in 78% of the specimens but was not associated with DSS. Ki-67 index varied between
Subject: 3122 Cancers
NEUROENDOCRINE TUMORS
CUSHINGS-SYNDROME
PROGNOSTIC-SIGNIFICANCE
KI67 REPRODUCIBILITY
AGGRESSIVE VARIANT
TTF-1 EXPRESSION
LUNG-CANCER
INDEX
DIAGNOSIS
SECONDARY
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