Vesterinen , T , Mononen , S , Salmenkivi , K , Mustonen , H , Ilonen , I , Knuuttila , A , Haglund , C & Arola , J 2018 , ' Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor ' , Acta Oncologica , vol. 57 , no. 8 , pp. 1109-1116 . https://doi.org/10.1080/0284186X.2018.1441543
Title: | Clinicopathological indicators of survival among patients with pulmonary carcinoid tumor |
Author: | Vesterinen, Tiina; Mononen, Sanna; Salmenkivi, Kaisa; Mustonen, Harri; Ilonen, Ilkka; Knuuttila, Aija; Haglund, Caj; Arola, Johanna |
Contributor organization: | HUSLAB Institute for Molecular Medicine Finland University of Helsinki Medicum Department of Pathology Clinicum Department of Surgery III kirurgian klinikka Department of Medicine Keuhkosairauksien yksikkö Doctoral Programme in Clinical Research Translational Cancer Biology (TCB) Research Programme II kirurgian klinikka Research Programs Unit HUS Heart and Lung Center HUS Comprehensive Cancer Center HUS Abdominal Center |
Date: | 2018 |
Language: | eng |
Number of pages: | 8 |
Belongs to series: | Acta Oncologica |
ISSN: | 0284-186X |
DOI: | https://doi.org/10.1080/0284186X.2018.1441543 |
URI: | http://hdl.handle.net/10138/240216 |
Abstract: | Background: Pulmonary carcinoids (PC) are rare malignant neoplasms that cover approximately 1% of all lung cancers. PCs are classified by histological criteria as either typical (TC) or atypical (AC). Histological subtype is the most studied prognostic factor. The aim of this study was to evaluate if other tissue or clinical features are associated with patient outcomes.Material and methods: We retrospectively reviewed clinical records of 133PC patients who underwent operation in the Helsinki University Hospital between 1990 and 2013. Tissue specimens were re-evaluated, processed into tissue microarray format and stained immunohistochemically with serotonin, calcitonin, adrenocorticotropic hormone (ACTH), thyroid transcription factor-1 (TTF-1) and Ki-67. Survival and risk analyses were performed.Results: Based on histology, 75% (n=100) of the tumors were TCs and 25% (n=33) ACs. TCs had higher 10-year disease-specific survival (DSS) rate than ACs (99% (95% CI, 93-100%) for TCs vs. 82% (95% CI, 61-92%) for ACs). Hormonally active tumors expressing serotonin, calcitonin or ACTH were noted in 53% of the specimens but hormonal expression was not associated with DSS. TTF-1 was positive in 78% of the specimens but was not associated with DSS. Ki-67 index varied between |
Description: | Correction: Volume: 58 Issue: 5 Pages: 819-819 Special Issue: SI DOI: 10.1080/0284186X.2019.1598134 Published: MAY 4 2019 |
Subject: |
3122 Cancers
NEUROENDOCRINE TUMORS CUSHINGS-SYNDROME PROGNOSTIC-SIGNIFICANCE KI67 REPRODUCIBILITY AGGRESSIVE VARIANT TTF-1 EXPRESSION LUNG-CANCER INDEX DIAGNOSIS SECONDARY |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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