Early life stress and frailty in old age : the Helsinki birth cohort study

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Haapanen , M J , Perälä , M M , Salonen , M K , Kajantie , E , Simonen , M , Pohjolainen , P , Pesonen , A K , Räikkönen , K , Eriksson , J G & von Bonsdorff , M B 2018 , ' Early life stress and frailty in old age : the Helsinki birth cohort study ' , BMC Geriatrics , vol. 18 , 179 . https://doi.org/10.1186/s12877-018-0873-5

Title: Early life stress and frailty in old age : the Helsinki birth cohort study
Author: Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Pesonen, A. K.; Räikkönen, K.; Eriksson, J. G.; von Bonsdorff, M. B.
Contributor organization: Department of General Practice and Primary Health Care
Lastentautien yksikkö
Children's Hospital
University of Helsinki
HUS Children and Adolescents
Department of Finnish, Finno-Ugrian and Scandinavian Studies
Hannes Tapani Lohi / Principal Investigator
Doctoral Programme Brain & Mind
Department of Psychology and Logopedics
Doctoral Programme in Clinical Research
Developmental Psychology Research Group
Research Programs Unit
Diabetes and Obesity Research Program
Johan Eriksson / Principal Investigator
Date: 2018-08-13
Language: eng
Number of pages: 8
Belongs to series: BMC Geriatrics
ISSN: 1471-2318
DOI: https://doi.org/10.1186/s12877-018-0873-5
URI: http://hdl.handle.net/10138/240221
Abstract: Background: Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods: Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12. 0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried's criteria. Results: Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions: These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.
Subject: Early life stress
Natural experiment
Risk factor
3121 General medicine, internal medicine and other clinical medicine
515 Psychology
3112 Neurosciences
3124 Neurology and psychiatry
5141 Sociology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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