Early life stress and frailty in old age : the Helsinki birth cohort study

Show full item record



Permalink

http://hdl.handle.net/10138/240221

Citation

Haapanen , M J , Perälä , M M , Salonen , M K , Kajantie , E , Simonen , M , Pohjolainen , P , Pesonen , A K , Räikkönen , K , Eriksson , J G & von Bonsdorff , M B 2018 , ' Early life stress and frailty in old age : the Helsinki birth cohort study ' , BMC Geriatrics , vol. 18 , 179 . https://doi.org/10.1186/s12877-018-0873-5

Title: Early life stress and frailty in old age : the Helsinki birth cohort study
Author: Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Pesonen, A. K.; Räikkönen, K.; Eriksson, J. G.; von Bonsdorff, M. B.
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Sociology
University of Helsinki, Doctoral Programme Brain & Mind
University of Helsinki, Medicum
University of Helsinki, Doctoral Programme in Clinical Research
Date: 2018-08-13
Language: eng
Number of pages: 8
Belongs to series: BMC Geriatrics
ISSN: 1471-2318
URI: http://hdl.handle.net/10138/240221
Abstract: Background: Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods: Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12. 0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried's criteria. Results: Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions: These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.
Subject: Early life stress
Frailty
Life-course
Natural experiment
Risk factor
ADVERSE CHILDHOOD EXPERIENCES
SEX-DIFFERENCES
ADULTS
INFLAMMATION
PREVALENCE
HEALTH
MALTREATMENT
DISABILITY
DEPRESSION
PHENOTYPE
3121 General medicine, internal medicine and other clinical medicine
515 Psychology
3112 Neurosciences
3124 Neurology and psychiatry
5141 Sociology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s12877_018_0873_5.pdf 581.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record