Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection

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dc.contributor.author Azinas, S.
dc.contributor.author Bano, F.
dc.contributor.author Torca, I.
dc.contributor.author Bamford, D. H.
dc.contributor.author Schwartz, G. A.
dc.contributor.author Esnaola, J.
dc.contributor.author Oksanen, H. M.
dc.contributor.author Richter, R. P.
dc.contributor.author Abrescia, N. G.
dc.date.accessioned 2018-08-31T08:24:01Z
dc.date.available 2018-08-31T08:24:01Z
dc.date.issued 2018-04-28
dc.identifier.citation Azinas , S , Bano , F , Torca , I , Bamford , D H , Schwartz , G A , Esnaola , J , Oksanen , H M , Richter , R P & Abrescia , N G 2018 , ' Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection ' , Nanoscale , vol. 10 , no. 16 , pp. 7769-7779 . https://doi.org/10.1039/c8nr00196k
dc.identifier.other PURE: 106956060
dc.identifier.other PURE UUID: 1c4979b0-0ae9-4981-bb9f-5e412581d0fa
dc.identifier.other WOS: 000431030000051
dc.identifier.other Scopus: 85046103137
dc.identifier.other ORCID: /0000-0002-6438-8118/work/50861388
dc.identifier.other ORCID: /0000-0003-3047-8294/work/50886773
dc.identifier.uri http://hdl.handle.net/10138/240369
dc.description.abstract The protection of the viral genome during extracellular transport is an absolute requirement for virus survival and replication. In addition to the almost universal proteinaceous capsids, certain viruses add a membrane layer that encloses their double-stranded (ds) DNA genome within the protein shell. Using the membrane-containing enterobacterial virus PRD1 as a prototype, and a combination of nanoindentation assays by atomic force microscopy and finite element modelling, we show that PRD1 provides a greater stability against mechanical stress than that achieved by the majority of dsDNA icosahedral viruses that lack a membrane. We propose that the combination of a stiff and brittle proteinaceous shell coupled with a soft and compliant membrane vesicle yields a tough composite nanomaterial well-suited to protect the viral DNA during extracellular transport. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Nanoscale
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ATOMIC-FORCE MICROSCOPY
dc.subject BACTERIOPHAGE PRD1
dc.subject HUMAN ADENOVIRUS
dc.subject WILD-TYPE
dc.subject PROTEIN
dc.subject DNA
dc.subject CAPSIDS
dc.subject PHAGE
dc.subject REINFORCEMENT
dc.subject QUANTITATION
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection en
dc.type Article
dc.contributor.organization Biosciences
dc.contributor.organization Molecular and Integrative Biosciences Research Programme
dc.contributor.organization Structure of the Viral Universe
dc.contributor.organization Molecular Principles of Viruses
dc.contributor.organization Aerovirology Research Group
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1039/c8nr00196k
dc.relation.issn 2040-3364
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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