Re: "Bias in clinical intervention research" : [Letter]

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Hemilä , H 2007 , ' Re: "Bias in clinical intervention research" : [Letter] ' , American Journal of Epidemiology , vol. 165 , no. 10 , pp. 1219-1219 . https://doi.org/10.1093/aje/kwm081

Title: Re: "Bias in clinical intervention research" : [Letter]
Author: Hemilä, Harri
Contributor: University of Helsinki, Department of Public Health
Date: 2007
Language: eng
Number of pages: 1
Belongs to series: American Journal of Epidemiology
ISSN: 0002-9262
URI: http://hdl.handle.net/10138/240921
Abstract: In her Journal review discussing the potential biases of controlled trials, Gluud stated that “[t]he purpose of blinding is to prevent bias associated with patients' and investigators' expectations. If interventions are compared with no intervention, an identical placebo may be used. The compared interventions must be identical in taste, smell, appearance, and mode of administration. Any difference may destroy the blinding”. The last sentence of this quotation was based on three references, two of them focusing on vitamin C and common cold trials. However, the Karlowski et al. trial and the Chalmers review were both shown to be erroneous a decade ago.
Subject: 314 Health sciences
3142 Public health care science, environmental and occupational health
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