Progress in Defining the Genetic Basis of Diabetic Complications

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Dahlstrom , E & Sandholm , N 2017 , ' Progress in Defining the Genetic Basis of Diabetic Complications ' , Current diabetes reports. , vol. 17 , no. 9 , 80 . https://doi.org/10.1007/s11892-017-0906-z

Title: Progress in Defining the Genetic Basis of Diabetic Complications
Author: Dahlstrom, Emma; Sandholm, Niina
Contributor organization: Nefrologian yksikkö
Department of Medicine
Clinicum
Research Programs Unit
Diabetes and Obesity Research Program
HUS Internal Medicine and Rehabilitation
HUS Abdominal Center
Date: 2017-09
Language: eng
Number of pages: 13
Belongs to series: Current diabetes reports.
ISSN: 1534-4827
DOI: https://doi.org/10.1007/s11892-017-0906-z
URI: http://hdl.handle.net/10138/241363
Abstract: Purpose of Review Diabetic complications affecting the kidneys, retina, nerves, and the cardiovasculature are the major causes of morbidity and mortality in diabetes. This paper aims to review the current understanding of the genetic basis of these complications, based on recent findings especially from genome-wide association studies. Recent Findings Variants in or near AFF3, RGMA-MCTP2, SP3-CDCA7, GLRA3, CNKSR3, and UMOD have reached genome-wide significance (p value <5 x 10(-8)) for association with diabetic kidney disease, and recently, GRB2 was reported to be associated at genome-wide significance with diabetic retinopathy. While some loci affecting cardiovascular disease in the general population have been replicated in diabetes, GLUL affects the risk of cardiovascular disease specifically in diabetic subjects. Summary Genetic findings are emerging for diabetic complications, although the studies remain relatively small compared to those for type 1 and type 2 diabetes. In addition to pinpointing specific loci, the studies also reveal biological information on correlated traits and pathways.
Subject: Genetic risk factors
Diabetic complications
Genome-wide association study
End-stage renal disease
Diabetic retinopathy
Cardiovascular disease
GENOME-WIDE ASSOCIATION
CORONARY-ARTERY-DISEASE
ANGIOTENSIN-CONVERTING ENZYME
INDEPENDENT RISK FACTOR
ALBUMIN EXCRETION RATE
ALL-CAUSE MORTALITY
CARDIOVASCULAR-DISEASE
KIDNEY-DISEASE
PERIPHERAL NEUROPATHY
HEART-DISEASE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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