PANNZER2 : a rapid functional annotation web server

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Törönen , P , Medlar , A & Holm , L 2018 , ' PANNZER2 : a rapid functional annotation web server ' , Nucleic Acids Research , vol. 46 , no. W1 , pp. W84-W88 .

Title: PANNZER2 : a rapid functional annotation web server
Author: Törönen, Petri; Medlar, Alan; Holm, Liisa
Contributor organization: Institute of Biotechnology
Computational genomics
Helsinki Institute of Life Science HiLIFE
Organismal and Evolutionary Biology Research Programme
Faculty of Biological and Environmental Sciences
Date: 2018-07-02
Language: eng
Number of pages: 5
Belongs to series: Nucleic Acids Research
ISSN: 0305-1048
Abstract: The unprecedented growth of high-throughput sequencing has led to an ever-widening annotation gap in protein databases. While computational prediction methods are available to make up the shortfall, a majority of public web servers are hindered by practical limitations and poor performance. Here, we introduce PANNZER2 (Protein ANNotation with ZscoRE), a fast functional annotation web server that provides both Gene Ontology (GO) annotations and free text description predictions. PANNZER2 uses SANSparallel to perform high-performance homology searches, making bulk annotation based on sequence similarity practical. PANNZER2 can output GO annotations from multiple scoring functions, enabling users to see which predictions are robust across predictors. Finally, PANNZER2 predictions scored within the top 10 methods for molecular function and biological process in the CAFA2 NK-full benchmark. The PANNZER2 web server is updated on a monthly schedule and is accessible at The source code is available under the GNU Public Licence v3.
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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