Micro-CT evaluation of asymmetrical ovine intervertebral disc height loss from surgical approach

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Ludtka , C , Schwan , S , Friedmann , A , Brehm , W , Wiesner , I & Goehre , F 2017 , ' Micro-CT evaluation of asymmetrical ovine intervertebral disc height loss from surgical approach ' , European Spine Journal , vol. 26 , no. 8 , pp. 2031-2037 . https://doi.org/10.1007/s00586-017-5024-8

Title: Micro-CT evaluation of asymmetrical ovine intervertebral disc height loss from surgical approach
Author: Ludtka, Christopher; Schwan, Stefan; Friedmann, Andrea; Brehm, Walther; Wiesner, Ingo; Goehre, Felix
Contributor: University of Helsinki, Department of Neurosciences
Date: 2017-08
Language: eng
Number of pages: 7
Belongs to series: European Spine Journal
ISSN: 0940-6719
URI: http://hdl.handle.net/10138/243404
Abstract: The primary goal of this study is to clearly define and evaluate new intervertebral disc height parameters in analysing the morphological pathology of disc degeneration for application in damage model and regeneration therapy development, as well as applying traditional variables to 3-D characterization methods. A posterolateral surgical approach was used to induce disc degeneration in an ovine model. At 12-months post-operation, sheep vertebral segments were removed and characterized using micro-CT to evaluate disc height parameters in regard to injury localization. Statistically significant differences between the disc height loss of the left and right side of the disc, consistent with the lateral surgical approach used were seen using the modified average disc height method by Dabbs et al. However, convexity index and the newly proposed Cross Tilt Index did not conclusively demonstrate a difference. Two-dimensional morphological evaluations can be applied in 3-D to provide a more complete picture of disc height loss for injury models. New 3-D parameters that are tailored to the type of surgical approach used should be investigated, with the 9-point system described herein providing a useful basis for derived values. Additionally, the surgical approach chosen when artificially injuring the disc can result in asymmetrical degeneration, as indicated by uneven disc height loss.
Subject: Intervertebral disc height
Micro-computed tomography
lCT
IVD degeneration
Animal model
Disc herniation
LUMBAR SPINE
STEM-CELLS
DEGENERATION
VOLUME
MODEL
SHAPE
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
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