Involvement of the Periaqueductal Gray in the Descending Antinociceptive Effect Induced by the Central Nucleus of Amygdala

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Bourbia , N & Pertovaara , A 2018 , ' Involvement of the Periaqueductal Gray in the Descending Antinociceptive Effect Induced by the Central Nucleus of Amygdala ' , Physiological Research , vol. 67 , no. 4 , pp. 647-655 . https://doi.org/10.33549/physiolres.933699

Title: Involvement of the Periaqueductal Gray in the Descending Antinociceptive Effect Induced by the Central Nucleus of Amygdala
Author: Bourbia, N.; Pertovaara, A.
Contributor: University of Helsinki, Department of Physiology
University of Helsinki, Antti Pertovaara / Principal Investigator
Date: 2018
Language: eng
Number of pages: 9
Belongs to series: Physiological Research
ISSN: 0862-8408
URI: http://hdl.handle.net/10138/243761
Abstract: Here we studied whether descending control of mechanical nociception by glutamate in the central nucleus of the amygdala (CeA) of healthy control animals is induced by amygdaloid NMDA receptors and relayed through the midbrain periaqueductal gray (PAG). Mechanical nociception in the hind paws was assessed in rats with chronic guide cannulae for glutamate administration in the right CeA and for inducing local anesthesia in the PAG. In a separate electrophysiological study, ON-like PAG neurons giving an excitatory response to noxious pinch of the tail were recorded in anesthetized rats following glutamate administration into the CeA. A high dose of glutamate (100 mu g) in the CeA induced mechanical antinociception in the contra- but not ipsilateral hind limb. Antinociception was prevented by an NMDA receptor antagonist in the CeA or local anesthesia of the PAG. Discharge rate of ON-like PAG neurons was increased by a high dose of glutamate (100 mu g) in the CeA and this increase was prevented by an NMDA receptor antagonist in the CeA. The results indicate that amygdaloid NMDA receptors in the CeA may induce contralaterally mechanical antinociception through a circuitry relaying in the PAG. Activation of ON-like PAG neurons is associated with the descending antinociceptive effect. Mechanisms and causality of this association still remain to be studied.
Subject: 3111 Biomedicine
1184 Genetics, developmental biology, physiology
Amygdala
Descending pain control
Mechanical nociception
N-methyl-D-aspartate receptor
Periaqueductal gray
PAIN
RAT
STIMULATION
RECEPTORS
NEURONS
NMDA
SUBMODALITY
ANTAGONISM
SUPPRESSES
ACTIVATION
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