Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin

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http://hdl.handle.net/10138/243762

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Hoornstra , D , Vesterlin , J , Parnanen , P , Al-Samadi , A , Zlotogorski-Hurvitz , A , Vered , M & Salo , T 2018 , ' Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin ' , In Vivo , vol. 32 , no. 5 , pp. 1089-1095 . https://doi.org/10.21873/invivo.11350

Title: Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin
Author: Hoornstra, Douwe; Vesterlin, Jenni; Parnanen, Pirjo; Al-Samadi, Ahmed; Zlotogorski-Hurvitz, Ayelet; Vered, Marilena; Salo, Tuula
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018
Language: eng
Number of pages: 7
Belongs to series: In Vivo
ISSN: 0258-851X
URI: http://hdl.handle.net/10138/243762
Abstract: Background: Oral tongue squamous cell carcinoma (OTSCC) cells are highly proliferative and invasive. Lingonberry contains several polyphenolic compounds similar to curcumin. We hypothesize that fermented lingonberry juice (FLJ) has an anti-invasive and anti-proliferative effect on OTSCC cells similarly to curcumin, which is known to be anti-carcinogenic. Materials and Methods: FLJ, curcumin dissolved in ethanol, or curcumin loaded in Candida extracellular vesicles (EVs) were added to more (HSC-3) and less aggressive (SCC-25) OTSCC cells. Cell proliferation was measured with a 5-bromo-2'-deoxyuridine kit and invasion in the three-dimensional Myogel spheroid assay. Statistical analyses were completed with one-way ANOVA and Bonferroni post-hoc testing. Results: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells. The effects of curcumin were not improved when cells were treated with curcumin loaded within EVs. Conclusion: Our results suggest that FLJ, like curcumin, has an anti-carcinogenic effect on aggressive OTSCC cells in vitro.
Subject: Oral cancer cells
anti-invasive
anti-proliferative
3D spheroid
LIPOSOMAL NANOPARTICLES
CANCER
OSTEOSARCOMA
BLUEBERRY
PATHWAYS
BERRIES
HEALTH
URINE
FRUIT
RISK
313 Dentistry
3111 Biomedicine
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