Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin

Show full item record



Permalink

http://hdl.handle.net/10138/243762

Citation

Hoornstra , D , Vesterlin , J , Parnanen , P , Al-Samadi , A , Zlotogorski-Hurvitz , A , Vered , M & Salo , T 2018 , ' Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin ' , In Vivo , vol. 32 , no. 5 , pp. 1089-1095 . https://doi.org/10.21873/invivo.11350

Title: Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin
Author: Hoornstra, Douwe; Vesterlin, Jenni; Parnanen, Pirjo; Al-Samadi, Ahmed; Zlotogorski-Hurvitz, Ayelet; Vered, Marilena; Salo, Tuula
Contributor organization: Department of Oral and Maxillofacial Diseases
Clinicum
HUS Head and Neck Center
Date: 2018
Language: eng
Number of pages: 7
Belongs to series: In Vivo
ISSN: 0258-851X
DOI: https://doi.org/10.21873/invivo.11350
URI: http://hdl.handle.net/10138/243762
Abstract: Background: Oral tongue squamous cell carcinoma (OTSCC) cells are highly proliferative and invasive. Lingonberry contains several polyphenolic compounds similar to curcumin. We hypothesize that fermented lingonberry juice (FLJ) has an anti-invasive and anti-proliferative effect on OTSCC cells similarly to curcumin, which is known to be anti-carcinogenic. Materials and Methods: FLJ, curcumin dissolved in ethanol, or curcumin loaded in Candida extracellular vesicles (EVs) were added to more (HSC-3) and less aggressive (SCC-25) OTSCC cells. Cell proliferation was measured with a 5-bromo-2'-deoxyuridine kit and invasion in the three-dimensional Myogel spheroid assay. Statistical analyses were completed with one-way ANOVA and Bonferroni post-hoc testing. Results: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells. The effects of curcumin were not improved when cells were treated with curcumin loaded within EVs. Conclusion: Our results suggest that FLJ, like curcumin, has an anti-carcinogenic effect on aggressive OTSCC cells in vitro.
Subject: Oral cancer cells
anti-invasive
anti-proliferative
3D spheroid
LIPOSOMAL NANOPARTICLES
CANCER
OSTEOSARCOMA
BLUEBERRY
PATHWAYS
BERRIES
HEALTH
URINE
FRUIT
RISK
313 Dentistry
3111 Biomedicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Fermented_Lingonberry_Juice_.pdf 523.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record