Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Show full item record



Permalink

http://hdl.handle.net/10138/243763

Citation

Huttunen , H J , Palva , J M , Lindberg , L , Palva , S , Saarela , V , Karvonen , E , Latvala , M-L , Liinamaa , J , Booms , S , Castren , E & Uusitalo , H 2018 , ' Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia ' , Scientific Reports , vol. 8 , 12830 . https://doi.org/10.1038/s41598-018-31169-z

Title: Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia
Author: Huttunen, Henri J.; Palva, J. Matias; Lindberg, Laura; Palva, Satu; Saarela, Ville; Karvonen, Elina; Latvala, Marja-Leena; Liinamaa, Johanna; Booms, Sigrid; Castren, Eero; Uusitalo, Hannu
Contributor: University of Helsinki, Doctoral Programme Brain & Mind
University of Helsinki, Doctoral Programme Brain & Mind
University of Helsinki, Silmäklinikka
University of Helsinki, Doctoral Programme Brain & Mind
University of Helsinki, Neuroscience Center
Date: 2018-08-27
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/243763
Abstract: Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: -0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (-0.167 logMAR; 95% CI: -0.226 to -0.108; p <0.001) and placebo (-0.194 logMAR; 95% CI: -0.254 to -0.133; p <0.001) groups. While this study failed to provide evidence that fluoxetine enhances neuroplasticity, our data support other recent clinical studies suggesting that improvement of vision can be accomplished in adults with amblyopia.
Subject: CHILDREN AGED 7
ANISOMETROPIC AMBLYOPIA
CONTRAST SENSITIVITY
RANDOMIZED-TRIAL
OLDER CHILDREN
TREAT AMBLYOPIA
CLINICAL-TRIAL
POPULATION
PREVALENCE
PLASTICITY
3112 Neurosciences
3125 Otorhinolaryngology, ophthalmology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_018_31169_z.pdf 2.634Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record