Effect of gestational diabetes mellitus on newborn cholesterol metabolism

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Miettinen , H E , Rono , K , Koivusalo , S B , Eriksson , J G & Gylling , H 2018 , ' Effect of gestational diabetes mellitus on newborn cholesterol metabolism ' , Atherosclerosis , vol. 275 , pp. 346-351 . https://doi.org/10.1016/j.atherosclerosis.2018.06.879

Title: Effect of gestational diabetes mellitus on newborn cholesterol metabolism
Author: Miettinen, Helena E.; Rono, Kristiina; Koivusalo, Saila B.; Eriksson, Johan G.; Gylling, Helena
Other contributor: University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of Medicine








Date: 2018-08
Language: eng
Number of pages: 6
Belongs to series: Atherosclerosis
ISSN: 0021-9150
DOI: https://doi.org/10.1016/j.atherosclerosis.2018.06.879
URI: http://hdl.handle.net/10138/245182
Abstract: Background and aims: Impaired glucose metabolism during pregnancy may associate with changes in fetal cholesterol metabolism. We investigated if gestational diabetes mellitus (GDM) affects newborn cholesterol metabolism as determined by cord blood squalene and non-cholesterol sterols. Furthermore, we examined potential correlations between cord blood and maternal serum non-cholesterol sterols. Methods: Pregnant women at risk for GDM (BMI>30 kg/m(2)) were enrolled from maternity clinics in Finland. GDM was determined from the results of an oral glucose tolerance test. Serum samples were taken in the third trimester of pregnancy, and cord blood samples collected from their newborns at birth. Squalene and non-cholesterol sterols were analyzed from serum and cord blood by gas liquid chromatography. All women with GDM were in good glycaemic control. Results: The ratios of squalene and non-cholesterol sterols to cholesterol (100 x mu mol/mmol of cholesterol) in cord blood did not differ between the infants born to mothers with GDM (n = 15) or mothers with normal glucose tolerance (n = 13). The ratios of sitosterol and campesterol to cholesterol in the cord blood correlated with the corresponding maternal serum ratios (r = 0.70, p <0.0001) in both groups. Conclusions: In obese women under good glycaemic control, GDM did not affect newborn cholesterol metabolism. Cord blood sitosterol and campesterol ratios to cholesterol correlated with the corresponding maternal serum ratios thus potentially reflecting maternal-fetal cholesterol transport. (C) 2018 Elsevier B.V. All rights reserved.
Subject: Pregnancy
Phytosterol
Cholesterol metabolism
Maternal-fetal cholesterol transport
Lipoprotein
Gestational diabetes mellitus
MATERNAL LIPOPROTEIN METABOLISM
ENDOTHELIAL-CELLS
HUMAN-PREGNANCY
FETAL
WOMEN
DESMOSTEROL
LIPIDS
BRAIN
3121 General medicine, internal medicine and other clinical medicine
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