RNA Interference as a Prospective Tool for the Control of Human Viral Infections

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http://hdl.handle.net/10138/246111

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Levanova , A & Poranen , M M 2018 , ' RNA Interference as a Prospective Tool for the Control of Human Viral Infections ' , Frontiers in Microbiology , vol. 9 , 2151 . https://doi.org/10.3389/fmicb.2018.02151

Title: RNA Interference as a Prospective Tool for the Control of Human Viral Infections
Author: Levanova, Alesia; Poranen, Minna M.
Contributor: University of Helsinki, Molecular and Translational Virology
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2018-09-11
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Microbiology
ISSN: 1664-302X
URI: http://hdl.handle.net/10138/246111
Abstract: RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
Subject: RNA interference
antiviral siRNA
antiviral shRNA
siRNA production
siRNA delivery
DOUBLE-STRANDED-RNA
RESPIRATORY SYNCYTIAL VIRUS
MAMMALIAN-CELLS
HEPATITIS-B
SIRNA DELIVERY
BACTERIOPHAGE PHI-6
ANTIVIRAL IMMUNITY
ESCHERICHIA-COLI
POLYMERASE
INHIBITION
1183 Plant biology, microbiology, virology
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