RNA Interference as a Prospective Tool for the Control of Human Viral Infections

Show full item record



Permalink

http://hdl.handle.net/10138/246111

Citation

Levanova , A & Poranen , M M 2018 , ' RNA Interference as a Prospective Tool for the Control of Human Viral Infections ' , Frontiers in Microbiology , vol. 9 , 2151 . https://doi.org/10.3389/fmicb.2018.02151

Title: RNA Interference as a Prospective Tool for the Control of Human Viral Infections
Author: Levanova, Alesia; Poranen, Minna M.
Contributor organization: Molecular and Translational Virology
Molecular and Integrative Biosciences Research Programme
Faculty of Biological and Environmental Sciences
Doctoral Programme in Microbiology and Biotechnology
General Microbiology
Date: 2018-09-11
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Microbiology
ISSN: 1664-302X
DOI: https://doi.org/10.3389/fmicb.2018.02151
URI: http://hdl.handle.net/10138/246111
Abstract: RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
Subject: RNA interference
antiviral siRNA
antiviral shRNA
siRNA production
siRNA delivery
DOUBLE-STRANDED-RNA
RESPIRATORY SYNCYTIAL VIRUS
MAMMALIAN-CELLS
HEPATITIS-B
SIRNA DELIVERY
BACTERIOPHAGE PHI-6
ANTIVIRAL IMMUNITY
ESCHERICHIA-COLI
POLYMERASE
INHIBITION
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
frmicb_09_02151.pdf 580.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record