Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

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http://hdl.handle.net/10138/246616

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He , L , Vanlandewijck , M , Mäe , M A , Andrae , J , Ando , K , Gaudio , F D , Nahar , K , Lebouvier , T , Laviña , B , Gouveia , L , Sun , Y , Raschperger , E , Segerstolpe , Å , Liu , J , Gustafsson , S , Räsänen , M , Zarb , Y , Mochizuki , N , Keller , A , Lendahl , U & Betsholtz , C 2018 , ' Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types ' , Scientific data , vol. 5 , 180160 . https://doi.org/10.1038/sdata.2018.160

Title: Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
Author: He, Liqun; Vanlandewijck, Michael; Mäe, Maarja Andaloussi; Andrae, Johanna; Ando, Koji; Gaudio, Francesca Del; Nahar, Khayrun; Lebouvier, Thibaud; Laviña, Bàrbara; Gouveia, Leonor; Sun, Ying; Raschperger, Elisabeth; Segerstolpe, Åsa; Liu, Jianping; Gustafsson, Sonja; Räsänen, Markus; Zarb, Yvette; Mochizuki, Naoki; Keller, Annika; Lendahl, Urban; Betsholtz, Christer
Contributor: University of Helsinki, Translational Cancer Biology (TCB) Research Programme
Date: 2018-08-21
Language: eng
Number of pages: 11
Belongs to series: Scientific data
ISSN: 2052-4463
URI: http://hdl.handle.net/10138/246616
Abstract: Vascular diseases are major causes of death, yet our understanding of the cellular constituents of blood vessels, including how differences in their gene expression profiles create diversity in vascular structure and function, is limited. In this paper, we describe a single-cell RNA sequencing (scRNA-seq) dataset that defines vascular and vessel-associated cell types and subtypes in mouse brain and lung. The dataset contains 3,436 single cell transcriptomes from mouse brain, which formed 15 distinct clusters corresponding to cell (sub) types, and another 1,504 single cell transcriptomes from mouse lung, which formed 17 cell clusters. In order to allow user-friendly access to our data, we constructed a searchable database (http://betsholtzlab.org/VascularSingleCells/database.html). Our dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
Subject: 1182 Biochemistry, cell and molecular biology
SEQ
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