Contribution of allelic imbalance to colorectal cancer
Pysyväisosoite
Lähdeviite
Palin , K , Pitkänen , E , Turunen , M , Sahu , B , Pihlajamaa , P , Kivioja , T , Kaasinen , E , Välimäki , N , Hänninen , U A , Cajuso , T , Aavikko , M , Tuupanen , S , Kilpivaara , O , van den Berg , L , Kondelin , J , Tanskanen , T , Katainen , R , Grau , M , Rauanheimo , H , Plaketti , R-M , Taira , A , Sulo , P , Hartonen , T , Dave , K , Schmierer , B , Botla , S , Sokolova , M , Vähärautio , A , Gladysz , K , Ongen , H , Dermitzakis , E , Bramsen , J B , Orntoft , T F , Andersen , C L , Ristimäki , A , Lepistö , A , Renkonen-Sinisalo , L , Mecklin , J-P , Taipale , J & Aaltonen , L A 2018 , ' Contribution of allelic imbalance to colorectal cancer ' , Nature Communications , vol. 9 , 3664 . https://doi.org/10.1038/s41467-018-06132-1
| Julkaisun nimi: | Contribution of allelic imbalance to colorectal cancer |
| Tekijä: | Palin, Kimmo; Pitkänen, Esa; Turunen, Mikko; Sahu, Biswajyoti; Pihlajamaa, Päivi; Kivioja, Teemu; Kaasinen, Eevi; Välimäki, Niko; Hänninen, Ulrika A.; Cajuso, Tatiana; Aavikko, Mervi; Tuupanen, Sari; Kilpivaara, Outi; van den Berg, Linda; Kondelin, Johanna; Tanskanen, Tomas; Katainen, Riku; Grau, Marta; Rauanheimo, Heli; Plaketti, Roosa-Maria; Taira, Aurora; Sulo, Päivi; Hartonen, Tuomo; Dave, Kashyap; Schmierer, Bernhard; Botla, Sandeep; Sokolova, Maria; Vähärautio, Anna; Gladysz, Kornelia; Ongen, Halit; Dermitzakis, Emmanouil; Bramsen, Jesper Bertram; Orntoft, Torben Falck; Andersen, Claus Lindbjerg; Ristimäki, Ari; Lepistö, Anna; Renkonen-Sinisalo, Laura; Mecklin, Jukka-Pekka; Taipale, Jussi; Aaltonen, Lauri A. |
| Tekijän organisaatio: | Research Programs Unit Lauri Antti Aaltonen / Principal Investigator Genome-Scale Biology (GSB) Research Program Department of Medical and Clinical Genetics Medicum University of Helsinki Doctoral Programme in Integrative Life Science Centre of Excellence in Stem Cell Metabolism Nutrient sensing laboratory Jussi Taipale / Principal Investigator Institute of Biotechnology Department of Pathology HUSLAB Gastrointestinal tumorigenesis Clinicum Doctoral Programme in Clinical Research Department of Surgery II kirurgian klinikka HUS Abdominal Center |
| Päiväys: | 2018-09-10 |
| Kieli: | eng |
| Sivumäärä: | 9 |
| Kuuluu julkaisusarjaan: | Nature Communications |
| ISSN: | 2041-1723 |
| DOI-tunniste: | https://doi.org/10.1038/s41467-018-06132-1 |
| URI: | http://hdl.handle.net/10138/247091 |
| Tiivistelmä: | Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (Al) landscape in 1699 colorectal cancers, 256 of which have been whole-genome sequenced (WGSed). The imbalances pinpoint 38 genes as plausible Al targets based on previous knowledge. Unbiased CRISPR-Cas9 knockout and activation screens identified in total 79 genes within Al peaks regulating cell growth. Genetic and functional data implicate loss of TP53 as a sufficient driver of Al. The WGS highlights an influence of copy number aberrations on the rate of detected somatic point mutations. Importantly, the data reveal several associations between Al target genes, suggesting a role for a network of lineage-determining transcription factors in colorectal tumorigenesis. Overall, the results unravel the contribution of Al in colorectal cancer and provide a plausible explanation why so few genes are commonly affected by point mutations in cancers. |
| Avainsanat: |
HUMAN-COLON
GENOME CELLS ENHANCERS GENES 3111 Biomedicine |
| Vertaisarvioitu: | Kyllä |
| Tekijänoikeustiedot: | cc_by |
| Pääsyrajoitteet: | openAccess |
| Rinnakkaistallennettu versio: | publishedVersion |
Tiedostot
Latausmäärä yhteensä: Ladataan...
| Tiedosto(t) | Koko | Formaatti | Näytä |
|---|---|---|---|
| s41467_018_06132_1.pdf | 792.2KB | Avaa tiedosto |
Viite kuuluu kokoelmiin:
-
TUHAT-artikkelit [50471]