Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene

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Oksanen , M , Hyötyläinen , I , Voutilainen , J , Puttonen , K A , Hämäläinen , R H , Graff , C , Lehtonen , S & Koistinaho , J 2018 , ' Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene ' , Stem Cell Research , vol. 31 , pp. 181-185 . https://doi.org/10.1016/j.scr.2018.07.024

Title: Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene
Author: Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A.; Hämäläinen, Riikka H.; Graff, Caroline; Lehtonen, Sarka; Koistinaho, Jari
Contributor organization: Neuroscience Center
University of Helsinki
Date: 2018-08
Language: eng
Number of pages: 5
Belongs to series: Stem Cell Research
ISSN: 1873-5061
DOI: https://doi.org/10.1016/j.scr.2018.07.024
URI: http://hdl.handle.net/10138/247099
Abstract: A double mutation (KM670/671NL) in amyloid precursor protein gene (APP) is causative for familial Alzheimer's disease and has been shown to increase the total A beta burden. Here we report the generation and characterization of an iPSC line from a fAD patient carrying APP KM670/671NL. The generated iPSCs retained the mutation, expressed pluripotency markers, showed a normal karyotype and differentiated into all three germ layers. This iPSC line can be used, for example, in disease modeling and mechanistic studies.
Subject: 3112 Neurosciences
3124 Neurology and psychiatry
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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