Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study

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Åström , M J , von Bonsdorff , M B , Perälä , M M , Salonen , M K , Rantanen , T , Kajantie , E , Simonen , M , Pohjolainen , P , Osmond , C & Eriksson , J G 2018 , ' Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study ' , Acta Diabetologica , vol. 55 , no. 10 , pp. 1051-1058 .

Title: Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study
Author: Åström, Max J.; von Bonsdorff, Mikaela B.; Perälä, Mia M.; Salonen, Minna K.; Rantanen, Taina; Kajantie, Eero; Simonen, Mika; Pohjolainen, Pertti; Osmond, Clive; Eriksson, Johan G.
Contributor organization: Department of General Practice and Primary Health Care
Lastentautien yksikkö
Children's Hospital
HUS Children and Adolescents
Hannes Tapani Lohi / Principal Investigator
Johan Eriksson / Principal Investigator
University of Helsinki
Date: 2018-10
Language: eng
Number of pages: 8
Belongs to series: Acta Diabetologica
ISSN: 1432-5233
Abstract: Aims To assess whether disturbances in glucose regulation are associated with impairment in physical performance during a 10-year follow-up. Methods 475 Men and 603 women from the Helsinki Birth Cohort Study were studied. Glucose regulation was evaluated with a 2-h 75-g oral glucose tolerance test (OGTT) in 2001-2004. Subjects were categorised as having either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), newly diagnosed diabetes or previously known diabetes. Physical performance was assessed approximately 10 years later using the validated senior fitness test (SFT). The relationship between glucose regulation and the overall SFT score was estimated using multiple linear regression models. Results The mean age was 70.8 years for men and 71.0 years for women when physical performance was assessed. The mean SFT score for the whole population was 45.0 (SD 17.5) points. The SFT score decreased gradually with increased impairment in glucose regulation. Individuals with previously known diabetes had the lowest overall SFT score in the fully adjusted model (mean difference compared to normoglycaemic individuals -11.56 points, 95% CI - 16.15 to - 6.98, p <0.001). Both individuals with newly diagnosed diabetes and individuals with IGT had significantly poorer physical performance compared to those with normoglycaemia. No significant difference in physical performance was found between those with IFG and those with normoglycaemia. Conclusions Among older people, impaired glucose regulation is strongly related with poor physical performance. More severe disturbances in glucose regulation are associated with a greater decrease in physical function, indicating the importance of diagnosing these disturbances at an early stage.
Subject: 3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Diabetes mellitus
Glucose intolerance
Glucose tolerance test
Physical fitness
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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