Circadian preference and sleep timing from childhood to adolescence in relation to genetic variants from a genome-wide association study

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http://hdl.handle.net/10138/247828

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Merikanto , I , Lahti , J , Kuula , L , Heinonen , K , Räikkönen , K , Andersson , S , Strandberg , T & Pesonen , A-K 2018 , ' Circadian preference and sleep timing from childhood to adolescence in relation to genetic variants from a genome-wide association study ' , Sleep Medicine , vol. 50 , pp. 36-41 . https://doi.org/10.1016/j.sleep.2018.04.015

Title: Circadian preference and sleep timing from childhood to adolescence in relation to genetic variants from a genome-wide association study
Author: Merikanto, Ilona; Lahti, Jari; Kuula, Liisa; Heinonen, Kati; Räikkönen, Katri; Andersson, Sture; Strandberg, Timo; Pesonen, Anu-Katriina
Contributor organization: Medicum
Department of Psychology and Logopedics
University of Helsinki
HUS Children and Adolescents
Children's Hospital
Lastentautien yksikkö
Clinicum
Timo Strandberg / Principal Investigator
Department of Medicine
HUS Internal Medicine and Rehabilitation
Developmental Psychology Research Group
Date: 2018-10
Language: eng
Number of pages: 6
Belongs to series: Sleep Medicine
ISSN: 1389-9457
DOI: https://doi.org/10.1016/j.sleep.2018.04.015
URI: http://hdl.handle.net/10138/247828
Abstract: Objective: Recent genome-wide association studies (GWASs) have revealed new genetic variants behind self-reported individual circadian preference, a distinct biological trait that is fairly stable during adulthood. In this study we analyze whether these genetic variants associate with objectively measured sleep timing from childhood to adolescence, over a nine-year period, with self-reported circadian preference during late adolescence. Methods: The participants (N = 100, 61% girls) came from a community cohort from Finland born in 1998. Sleep midpoint was measured with actigraphy at 8, 12 and 17 years. Circadian preference was self-reported at the age of 17 years. Single nucleotide polymorphisms (SNPs) were extracted at 12 years of age from the Illumina OmniExpress Exome 1.2 bead array data. Weighted polygenic risk scores (PRSs) were calculated based on top SNPs from a recent GWAS for morningness-eveningness in an adult population. Results: The PRS for circadian preference towards morningness was associated with earlier sleep midpoint from childhood to adolescence. When the time points were analyzed separately, the association between genetic tendency towards morning preference and earlier sleep midpoint was strongest among the 17-year-olds. Furthermore, the shift towards later sleep rhythm from early to late adolescence was milder for those with a higher PRS for morning preference. PRS for morning preference was also associated with self-reported circadian preference towards morningness in late adolescence. Conclusion: Our results suggest that genetic variants found for circadian preference in adults are already associated with objective sleep timing during childhood and adolescence, and predict individual developmental sleep trajectories from childhood onwards. (C) 2018 Published by Elsevier B.V.
Subject: Actigraphy
Chronotype
Circadian rhythm
Longitudinal
Polygenic risk score
Sleep midpoint
MORNINGNESS-EVENINGNESS
CLOCK
CRYPTOCHROME
CHRONOTYPES
EXPRESSION
PATTERNS
REVEALS
RHYTHMS
PERIOD
FBXL3
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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