Antibiotic resistance in the wild: an eco-evolutionary perspective

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Hiltunen , T , Virta , M & Laine , A-L 2017 , ' Antibiotic resistance in the wild: an eco-evolutionary perspective ' , Philosophical Transactions of the Royal Society. Biological Sciences , vol. 372 , no. 1712 , 20160039 .

Title: Antibiotic resistance in the wild: an eco-evolutionary perspective
Author: Hiltunen, Teppo; Virta, Marko; Laine, Anna-Liisa
Contributor organization: Department of Food and Nutrition
Environmental Sciences
Antibiotic resistance in human impacted environments
Anna-Liisa Laine / Principal Investigator
Centre of Excellence in Metapopulation Research
Ecology and Evolutionary Biology
Viikki Plant Science Centre (ViPS)
Date: 2017-01-19
Language: eng
Number of pages: 7
Belongs to series: Philosophical Transactions of the Royal Society. Biological Sciences
ISSN: 0962-8436
Abstract: The legacy of the use and misuse of antibiotics in recent decades has left us with a global public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat infections. At the same time, evolution of antibiotic resistance is probably the best-documented case of contemporary evolution. To date, research on antibiotic resistance has largely ignored the complexity of interactions that bacteria engage in. However, in natural populations, bacteria interact with other species; for example, competition and grazing are import interactions influencing bacterial population dynamics. Furthermore, antibiotic leakage to natural environments can radically alter bacterial communities. Overall, we argue that eco-evolutionary feedback loops in microbial communities can be modified by residual antibiotics and evolution of antibiotic resistance. The aim of this review is to connect some of the well-established key concepts in evolutionary biology and recent advances in the study of eco-evolutionary dynamics to research on antibiotic resistance. We also identify some key knowledge gaps related to eco-evolutionary dynamics of antibiotic resistance, and review some of the recent technical advantages in molecular microbiology that offer new opportunities for tackling these questions. Finally, we argue that using the full potential of evolutionary theory and active communication across the different fields is needed for solving this global crisis more efficiently. This article is part of the themed issue 'Human influences on evolution, and the ecological and societal consequences'.
Subject: antimicrobial resistance
horizontal gene transfer
eco-evolutionary dynamics
microbial community dynamics
sub-inhibitory antibiotics
1181 Ecology, evolutionary biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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