Antibiotic resistance in the wild: an eco-evolutionary perspective

Show simple item record Hiltunen, Teppo Virta, Marko Laine, Anna-Liisa 2018-10-09T10:49:01Z 2018-10-09T10:49:01Z 2017-01-19
dc.identifier.citation Hiltunen , T , Virta , M & Laine , A-L 2017 , ' Antibiotic resistance in the wild: an eco-evolutionary perspective ' , Philosophical Transactions of the Royal Society. Biological Sciences , vol. 372 , no. 1712 , 20160039 .
dc.identifier.other PURE: 78549390
dc.identifier.other PURE UUID: a16ab099-23a8-4899-bc1c-b2a8230af40e
dc.identifier.other WOS: 000390321500012
dc.identifier.other Scopus: 85006062522
dc.identifier.other ORCID: /0000-0001-5981-7566/work/29929383
dc.description.abstract The legacy of the use and misuse of antibiotics in recent decades has left us with a global public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat infections. At the same time, evolution of antibiotic resistance is probably the best-documented case of contemporary evolution. To date, research on antibiotic resistance has largely ignored the complexity of interactions that bacteria engage in. However, in natural populations, bacteria interact with other species; for example, competition and grazing are import interactions influencing bacterial population dynamics. Furthermore, antibiotic leakage to natural environments can radically alter bacterial communities. Overall, we argue that eco-evolutionary feedback loops in microbial communities can be modified by residual antibiotics and evolution of antibiotic resistance. The aim of this review is to connect some of the well-established key concepts in evolutionary biology and recent advances in the study of eco-evolutionary dynamics to research on antibiotic resistance. We also identify some key knowledge gaps related to eco-evolutionary dynamics of antibiotic resistance, and review some of the recent technical advantages in molecular microbiology that offer new opportunities for tackling these questions. Finally, we argue that using the full potential of evolutionary theory and active communication across the different fields is needed for solving this global crisis more efficiently. This article is part of the themed issue 'Human influences on evolution, and the ecological and societal consequences'. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Philosophical Transactions of the Royal Society. Biological Sciences
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject antimicrobial resistance
dc.subject horizontal gene transfer
dc.subject eco-evolutionary dynamics
dc.subject evolution
dc.subject microbial community dynamics
dc.subject sub-inhibitory antibiotics
dc.subject BACTERIA
dc.subject ENVIRONMENT
dc.subject DYNAMICS
dc.subject GENES
dc.subject SELECTION
dc.subject MODEL
dc.subject 1ST
dc.subject ERA
dc.subject 1181 Ecology, evolutionary biology
dc.title Antibiotic resistance in the wild: an eco-evolutionary perspective en
dc.type Review Article
dc.contributor.organization Department of Food and Nutrition
dc.contributor.organization Environmental Sciences
dc.contributor.organization Antibiotic resistance in human impacted environments
dc.contributor.organization Biosciences
dc.contributor.organization Anna-Liisa Laine / Principal Investigator
dc.contributor.organization Centre of Excellence in Metapopulation Research
dc.contributor.organization Ecology and Evolutionary Biology
dc.contributor.organization Viikki Plant Science Centre (ViPS)
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0962-8436
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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