Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

Show full item record



Permalink

http://hdl.handle.net/10138/248094

Citation

Lovric , A , Graner , M , Bjornson , E , Arif , M , Benfeitas , R , Nyman , K , Ståhlman , M , Pentikäinen , M O , Lundbom , J , Hakkarainen , A , Siren , R , Nieminen , M S , Lundbom , N , Lauerma , K , Taskinen , M-R , Mardinoglu , A & Boren , J 2018 , ' Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome ' , Scientific Reports , vol. 8 , 14200 . https://doi.org/10.1038/s41598-018-31865-w

Title: Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
Author: Lovric, Alen; Graner, Marit; Bjornson, Elias; Arif, Muhammad; Benfeitas, Rui; Nyman, Kristofer; Ståhlman, Marcus; Pentikäinen, Markku O.; Lundbom, Jesper; Hakkarainen, Antti; Siren, Reijo; Nieminen, Markku S.; Lundbom, Nina; Lauerma, Kirsi; Taskinen, Marja-Riitta; Mardinoglu, Adil; Boren, Jan
Other contributor: University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, University of Helsinki
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum









Date: 2018-09-21
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-31865-w
URI: http://hdl.handle.net/10138/248094
Abstract: Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-beta 1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.
Subject: GROWTH-FACTOR 21
MYOCARDIAL TRIGLYCERIDE CONTENT
TYPE-2 DIABETES-MELLITUS
LIVER-DISEASE
INSULIN-RESISTANCE
CARDIOVASCULAR-DISEASE
MASS-SPECTROMETRY
ADIPOSE-TISSUE
CARDIAC STEATOSIS
SKELETAL-MUSCLE
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_018_31865_w_1.pdf 2.965Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record